Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Li-ke Qu"'
Autor:
Shan-Mei, Chen, Jun-Nan, Feng, Chuan-Ke, Zhao, Li-Cheng, Yao, Li-Xin, Wang, Lin, Meng, Shao-Qing, Cai, Cai-Yun, Liu, Li-Ke, Qu, Yan-Xing, Jia, Cheng-Chao, Shou
Publikováno v:
American journal of cancer research. 12(11)
Cancer is one of the main causes of death in humans worldwide, the development of more effective anticancer drugs that can inhibit the malignant progression of cancer cells is of great significance. Aiphanol is a natural product identified from the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::786aca85074c696410891636c7e25052
https://pubmed.ncbi.nlm.nih.gov/36504899
https://pubmed.ncbi.nlm.nih.gov/36504899
Autor:
Shan-mei Chen, Chuan-ke Zhao, Li-cheng Yao, Li-xin Wang, Yu-nan Ma, Lin Meng, Shao-qing Cai, Cai-yun Liu, Li-ke Qu, Yan-xing Jia, Cheng-chao Shou
Publikováno v:
Acta pharmacologica Sinica.
The high incidence of lymphatic metastasis is closely related to poor prognosis and mortality in cancers. Potent inhibitors to prevent pathological lymphangiogenesis and lymphatic spread are urgently needed. The VEGF-C-VEGFR3 pathway plays a vital ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f316adeed0630d1b92066ed8714632
https://pubmed.ncbi.nlm.nih.gov/35778489
https://pubmed.ncbi.nlm.nih.gov/35778489
Autor:
Tang, Jun1, Li-Ke Qu1, Zhang, Jianke2, Wang, Wenge3, Michaelson, Jennifer S.1, Degenhardt, Yan Y.4, El-Deiry, Wafik S.3, Xiaolu Yang1 xyang@mail.med.upenn.edu
Publikováno v:
Nature Cell Biology. Aug2006, Vol. 8 Issue 8, p855-862. 8p. 3 Diagrams, 2 Graphs.
Autor:
Li-Ke Qu, Andreas I. Papadakis, Shirin Kazemi, Antonis E. Koromilas, Dionissios Baltzis, Olivier Pluquet
Publikováno v:
Journal of Biological Chemistry. 282:31675-31687
Phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) is mediated by a family of kinases that respond to various forms of environmental stress. The eIF2alpha kinases are critical for mRNA translation, cell proliferation, and apoptosis. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5fafc005741521d03229bd0c59a9a3
https://doi.org/10.1074/jbc.m704491200
https://doi.org/10.1074/jbc.m704491200
Autor:
Shuo Wang, Jennifer F. Raven, Andrew Hoi-Tao Wong, Dionissios Baltzis, Suiyang Li, Qiaozhu Su, Antonis E. Koromilas, Li Ke Qu
Publikováno v:
EMBO reports. 8:265-270
The interferon (IFN)-inducible, double-stranded RNA activated protein kinase (PKR) is a dual-specificity kinase, which has an essential role in the regulation of protein synthesis by phosphorylating the translation eukaryotic initiation factor 2 (eIF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32d6086e4fbe01376aef13c4a9f2f3a
https://doi.org/10.1038/sj.embor.7400891
https://doi.org/10.1038/sj.embor.7400891
Publikováno v:
Molecular and Cellular Biology. 25:9392-9405
Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503720e1a78f930db9e60fdf69fb5a53
https://doi.org/10.1128/mcb.25.21.9392-9405.2005
https://doi.org/10.1128/mcb.25.21.9392-9405.2005
Autor:
Li-Ke Qu, Jaime D. Blais, John C. Bell, Antonis E. Koromilas, Stavroula Papadopoulou, Dionissios Baltzis, Nahum Sonenberg
Publikováno v:
Journal of Virology. 78:12747-12761
Phosphorylation of the alpha (α) subunit of the eukaryotic translation initiation factor 2 (eIF2) leads to the inhibition of protein synthesis in response to diverse stress conditions, including viral infection. The eIF2α kinase PKR has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5391c4760a09db57dcd90e5f896cb0
https://doi.org/10.1128/jvi.78.23.12747-12761.2004
https://doi.org/10.1128/jvi.78.23.12747-12761.2004
Autor:
Li-Ke Qu, Antonis E. Koromilas
Publikováno v:
Cell Cycle. 3:565-568
Alterations in the homeostasis of the endoplasmic reticulum (ER) by various forms of stress can lead to the accumulation of unfolded proteins and protein aggregates that are detrimental to cell survival. Eukaryotic cells can adapt to ER stress by act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab4eedfb767c6966c8d5aed62a1fcdf
https://doi.org/10.4161/cc.3.5.872
https://doi.org/10.4161/cc.3.5.872
Autor:
Yoichi Taya, Antonis E. Koromilas, Akihiko Yoshimura, Maria Hatzoglou, Dionissios Baltzis, Ana Maria Rivas-Estilla, Olivier Pluquet, Li Ke Qu, Costas Koumenis, Shirley Huang
Publikováno v:
Genes & Development. 18:261-277
The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cacd0dc928fc91060684ba03033ec1
https://doi.org/10.1101/gad.1165804
https://doi.org/10.1101/gad.1165804
Publikováno v:
Oncogene. 22:3721-3733
2-Aminopurine (2-AP) is an adenine analog shown to cause cells to bypass chemical- and radiation-induced cell cycle arrest through as-yet unidentified mechanisms. 2-AP has also been shown to act as a kinase inhibitor. Tumor suppressor p53 plays an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8689961ac9b65093c9e5fb45c929cb2
https://doi.org/10.1038/sj.onc.1206490
https://doi.org/10.1038/sj.onc.1206490