Zobrazeno 1 - 10
of 622
pro vyhledávání: '"Li-Tzong Chen"'
Autor:
Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang, Li-Tzong Chen
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-14 (2024)
Abstract Background Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population. Methods Exome sequ
Externí odkaz:
https://doaj.org/article/df7f60f9ec36445e8735f2495587c8d3
Autor:
Yuhling Wang, Shaoyu Yen, Yen-Yu Ian Shih, Chien-Wen Lai, Yu-Lin Chen, Li-Tzong Chen, Hsi Chen, Lun-De Liao
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110033- (2024)
Summary: Ischemic stroke can cause depolarized brain waves, termed peri-infarct depolarization (PID). Here, we evaluated whether topiramate, a neuroprotective drug used to treat epilepsy and alleviate migraine, has the potential to reduce PID. We emp
Externí odkaz:
https://doaj.org/article/0e60c7a8c28b4bc292323ff95a6f0ea3
Autor:
Shih‐Han Hsu, Ya‐Li Tsai, Yeng‐Tseng Wang, Che‐Hung Shen, Yu‐Hsuan Hung, Li‐Tzong Chen, Wen‐Chun Hung
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract RING finger 43 (RNF43), a RING‐type E3 ubiquitin ligase, is a key regulator of WNT signaling and is mutated in 6–10% of pancreatic tumors. However, RNF43‐mediated effects remain unclear, as only a few in vivo substrates of RNF43 are id
Externí odkaz:
https://doaj.org/article/33bc55e53bd24c3dab378361f3498788
Autor:
Tsung-Hao Liu, San-Chi Chen, Kun-Ming Rau, Li-Chun Lu, Po-Ting Lin, Yung-Yeh Su, Wei Teng, Shiue-Wei Lai, Ren-Hua Yeh, Tsui-Mai Kao, Pei-Chang Lee, Chi-Jung Wu, Chien-Hung Chen, Chih-Hung Hsu, Shi-Ming Lin, Yi-Hsiang Huang, Li-Tzong Chen, Ann-Lii Cheng, Ying-Chun Shen
Publikováno v:
Liver Cancer (2024)
Introduction The progression patterns, dispositions, and outcomes of patients with advanced hepatocellular carcinoma (HCC) who achieved durable responses with immunotherapy remain poorly characterized. Methods Patients with advanced HCC who received
Externí odkaz:
https://doaj.org/article/982567d91e37462383001cc9dc3d4719
Autor:
Chih‐Chieh Yen, Yi‐Hsin Yang, Hsiu‐Ying Ku, Huang‐Ming Hu, Su‐Shun Lo, Hung‐Chi Chang, Yee Chao, Jen‐Shi Chen, Hsiu‐Po Wang, Tsang‐En Wang, Li‐Yuan Bai, Ming‐Shiang Wu, Chia‐Jui Yen, Li‐Tzong Chen, Yan‐Shen Shan
Publikováno v:
Cancer Medicine, Vol 12, Iss 16, Pp 16906-16917 (2023)
Abstract Background Gastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population‐based cohort study aimed to clarify the
Externí odkaz:
https://doaj.org/article/afd010633a3f46fc98458e76aa241873
Autor:
Hui-Ching Wang, Sin-Hua Moi, Leong-Perng Chan, Chun-Chieh Wu, Jeng-Shiun Du, Pei-Lin Liu, Meng-Chun Chou, Che-Wei Wu, Chih-Jen Huang, Hui-Hua Hsiao, Mei-Ren Pan, Li-Tzong Chen
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 5, Pp 926-938 (2023)
Abstract Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of geneti
Externí odkaz:
https://doaj.org/article/dd67ea58412e4df8bdb746191a66b1d3
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 3, p 224 (2024)
Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even though surgery, chemotherapy, and targeted therapy are available for their treatments, these approaches provide limited success in reducing mortality, making
Externí odkaz:
https://doaj.org/article/28ffb7ca28b449108f587a444bc28c02
Autor:
Lyn Ley Lam, Nick Pavlakis, Kohei Shitara, Katrin M. Sjoquist, Andrew J. Martin, Sonia Yip, Yoon-Koo Kang, Yung-Jue Bang, Li-Tzong Chen, Markus Moehler, Tanios Bekaii-Saab, Thierry Alcindor, Christopher J. O’Callaghan, Niall C. Tebbutt, Wendy Hague, Howard Chan, Sun Young Rha, Keun-Wook Lee, Val Gebski, Anthony Jaworski, John Zalcberg, Timothy Price, John Simes, David Goldstein
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Advanced gastro-oesophageal cancer (AGOC) carries a poor prognosis. No standard of care treatment options are available after first and second-line therapies. Regorafenib is an oral multi-targeted tyrosine kinase inhibitor targeti
Externí odkaz:
https://doaj.org/article/b8e8b11dcadf410b83fe55a98f0861f4
Autor:
Chi-Che Hsieh, Yue-Chiu Su, Kuan-Ying Jiang, Takamichi Ito, Ting-Wei Li, Yumiko Kaku-Ito, Shih-Tsung Cheng, Li-Tzong Chen, Daw-Yang Hwang, Che-Hung Shen
Publikováno v:
Journal of Advanced Research, Vol 43, Iss , Pp 45-57 (2023)
Introduction: Acral melanoma is a predominant and aggressive subtype of melanoma in non-Caucasian populations. There is a lack of genotype-driven therapies for over 50% of patients. TRPM1 (transient receptor potential melastatin 1), a nonspecific cat
Externí odkaz:
https://doaj.org/article/45f85d2e01b84468a49f262c71d68593
Autor:
Yuichi Ichinose, Yi-Hsin Yang, Hui-Jen Tsai, Ru-Yu Huang, Takahiro Higashi, Toshirou Nishida, Li-Tzong Chen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Tyrosine kinase inhibitors (TKIs) improve the prognosis of patients with gastrointestinal stromal tumors (GISTs). We conducted a retrospective cohort study using cancer registries linked with health utilization data in Japan and Taiwan to as
Externí odkaz:
https://doaj.org/article/25f7c3f93b6541e1b8a4895347a7ecab