Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Li-Ru Zhao"'
Autor:
Xuefang Sophie Ren, Junchi He, Songruo Li, Heng Hu, Michele Kyle, Shinichi Kohsaka, Li-Ru Zhao
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8898 (2024)
Monocytes are circulating macrophage precursors generated from bone marrow hematopoietic stem cells. In adults, monocytes continuously replenish cerebral border-associated macrophages under physiological conditions. Monocytes also rapidly infiltrate
Externí odkaz:
https://doaj.org/article/cefa4acf2b8f45bcbc6be1f6f536e989
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 827 (2024)
Alzheimer’s disease (AD) leads to progressive neurodegeneration and dementia. AD primarily affects older adults with neuropathological changes including amyloid-beta (Aβ) deposition, neuroinflammation, and neurodegeneration. We have previously dem
Externí odkaz:
https://doaj.org/article/a596bc30578740079732c2b08f217e65
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-25 (2021)
Abstract Traumatic brain injury (TBI) is a major cause of long-term disability in young adults. An evidence-based treatment for TBI recovery, especially in the chronic phase, is not yet available. Using a severe TBI mouse model, we demonstrate that t
Externí odkaz:
https://doaj.org/article/7caf3b1737454fd8b47cdbfbe248b01e
Publikováno v:
Cells, Vol 12, Iss 5, p 705 (2023)
Severe traumatic brain injury (TBI) causes long-term disability and death in young adults. White matter is vulnerable to TBI damage. Demyelination is a major pathological change of white matter injury after TBI. Demyelination, which is characterized
Externí odkaz:
https://doaj.org/article/159114c851f24654a2944d90c1d4e983
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is a Notch3 mutation-induced cerebral small vessel disease, leading to recurrent ischemic stroke and vascular dementia. There is currently no treatmen
Externí odkaz:
https://doaj.org/article/866ddeba3a804b1580d3736b77158130
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is a cerebral small vascular disease caused by NOTCH3 gene mutation in vascular smooth muscle cells (VSMCs), leading to ischemic stroke and vascular d
Externí odkaz:
https://doaj.org/article/0103d51b30eb40979fb9bc15ab163ae5
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a cerebral small vascular disease caused by NOTCH3 mutation-induced vascular smooth muscle cell (VSMC) degeneration, leading to ischemic stroke an
Externí odkaz:
https://doaj.org/article/e042835f25944c21818c01174da994fa
Autor:
Xiao-Yun Liu, Maria E. Gonzalez-Toledo, Austin Fagan, Wei-Ming Duan, Yanying Liu, Siyuan Zhang, Bin Li, Chun-Shu Piao, Lila Nelson, Li-Ru Zhao
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 189-203 (2015)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a Notch3 dominant mutation-induced cerebral small vascular disease, is characterized by progressive degeneration of vascular smooth muscle cells (vS
Externí odkaz:
https://doaj.org/article/cad0761304f545f297fc33c9fa848b50
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and sw
Externí odkaz:
https://doaj.org/article/974babb80ac0411dafcdc5a6c9fe0029
Publikováno v:
ASN Neuro, Vol 8 (2016)
Stroke, a leading cause of adult disability in the world, is a severe medical condition with limited treatment. Physical therapy, the only treatment available for stroke rehabilitation, appears to be effective within 6 months post-stroke. Here, we ha
Externí odkaz:
https://doaj.org/article/d640174845d44ff98599c6a08d0de997