Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Li-Rong Shao"'
Autor:
Li-Rong Shao, Feng Gao, Viveka Chinnasamy, Yasuhiro Kazuki, Mistuo Oshimura, Roger H. Reeves, Carl E. Stafstrom
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106198- (2023)
Children with Down syndrome (DS, trisomy of chromosome 21) have an increased risk of infantile spasms (IS). As an epileptic encephalopathy, IS may further impair cognitive function and exacerbate neurodevelopmental delays already present in children
Externí odkaz:
https://doaj.org/article/11c1f9952d6547a59d297f251d21842c
Publikováno v:
Epilepsia Open, Vol 7, Iss 1, Pp 181-186 (2022)
Abstract Infantile spasms (IS) is an epileptic encephalopathy with a poor neurodevelopmental prognosis, and limited, often ineffective treatment options. The effectiveness of metabolic approaches to seizure control is being increasingly shown in a wi
Externí odkaz:
https://doaj.org/article/7cd5f3d6454a4e1195e5b34d3bf1f025
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Current anti-seizure drugs (ASDs) are believed to reduce neuronal excitability through modulation of ion channels and transporters that regulate excitability at the synaptic level. While most patients with epilepsy respond to ASDs, many remain refrac
Externí odkaz:
https://doaj.org/article/c23e8b06acb24a82ad84c994106fc324
Publikováno v:
Children, Vol 7, Iss 1, p 5 (2020)
Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic features, which affects children in the middle of the first year of life. The pathophysiology of IS remains incompletely understood, despite the heterogeneit
Externí odkaz:
https://doaj.org/article/90da4a72409349a99e02457fb0aba4be
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppres
Externí odkaz:
https://doaj.org/article/44d7a1b54f2243a98587ee0f0dcb095c
Publikováno v:
Children, Vol 6, Iss 2, p 23 (2019)
Mechanisms underlying seizures and epilepsy have traditionally been considered to involve abnormalities of ion channels or synaptic function. Those considerations gave rise to the excitation/inhibition (E/I) imbalance theory, whereby increased excita
Externí odkaz:
https://doaj.org/article/4ed8fa7914f74f6ca5f1ff06cd2ac237
Autor:
Li-Rong Shao, F. Edward Dudek
Publikováno v:
Journal of neurophysiology. 128(6)
Burst discharges in the developing brain can provide valuable insights into epileptogenesis. We show that the immature hippocampal CA1 area is capable of generating all-or-none (i.e., network) bursts, which transitions to graded (i.e., nonnetwork) bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ca9147423518b0af1954e3675ff527
https://pubmed.ncbi.nlm.nih.gov/36382903
https://pubmed.ncbi.nlm.nih.gov/36382903
Publikováno v:
Journal of Neurophysiology.
Inhibition of glycolysis with 2-deoxyglucose (2-DG) produces anti-seizure effects in brain slices and animal models, yet the mechanisms remain elusive. Here, we examined two glycolysis-derived ATP-associated mechanisms: vacuole ATP pump (V-ATPase) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b959123936a73716dc1bc57ce5eb7a28
https://doi.org/10.1152/jn.00124.2023
https://doi.org/10.1152/jn.00124.2023
Publikováno v:
Journal of Neurophysiology. 125:1-11
Despite the extensive literature showing the importance of the Na+-K+ pump in various neuronal functions, its roles in the developing brain are not well understood. This study reveals that the Na+-K+ pump differentially regulates the excitability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4487d18d20f3030b9651c76f335704cd
https://doi.org/10.1152/jn.00453.2020
https://doi.org/10.1152/jn.00453.2020
Publikováno v:
Ketogenic Diet and Metabolic Therapies ISBN: 0197501206
Numerous metabolic approaches have been employed clinically for seizure suppression, including the ketogenic diet (KD). Inhibiting or bypassing glycolysis may be one way by which the KD suppresses seizures. 2-Deoxy-d-glucose (2DG) is a glucose analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b329fb311e596918a31d64a29833f876
https://doi.org/10.1093/med/9780197501207.003.0038
https://doi.org/10.1093/med/9780197501207.003.0038
