Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Li-Man Hung"'
Autor:
Chih-Chun Chang, Chieh-Yu Chang, Pei-Chun Lin, Jiung-Pang Huang, Kuan-Hsing Chen, Tzung-Hai Yen, Li-Man Hung
Publikováno v:
Chinese Journal of Physiology, Vol 63, Iss 4, Pp 149-155 (2020)
Resveratrol (RSV) has been demonstrated to ameliorate nonalcoholic fatty liver disease (NAFLD) in animal studies. However, RSV was given with the dosage that ranged from 7 to 300 mg/kg body weight (BW). Hence, the study aimed to investigate the effic
Externí odkaz:
https://doaj.org/article/e4a7c11427544fc18871fcb96687784a
Autor:
Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo, Yung-Hsin Yeh
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-14 (2019)
Abstract Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear. Methods We investigated the corresponding mechani
Externí odkaz:
https://doaj.org/article/d307551a71664362856544127d40bc2d
Autor:
Huanhuan Ma, Jia Zhang, Lin Zhou, Shixiong Wen, Hsiang-Yu Tang, Bin Jiang, Fengqiong Zhang, Muhammad Suleman, Dachao Sun, Ai Chen, Wentao Zhao, Furong Lin, Ming-Tong Tsau, Lu-Min Shih, Changchuan Xie, Xiaotong Li, Donghai Lin, Li-Man Hung, Mei-Ling Cheng, Qinxi Li
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4235-4249.e6 (2020)
Summary: Reprogramming of glucose metabolism is a key event in tumorigenesis and progression. Here, we show that active c-Src stimulates glycolysis by phosphorylating (Tyr194) and activating PFKFB3, a key enzyme that boosts glycolysis by producing fr
Externí odkaz:
https://doaj.org/article/5477ea98c1d441bd9af6009acce7e0fb
Autor:
Zhentao Yang, Bin Jiang, Yan Wang, Hengxiao Ni, Jia Zhang, Jinmei Xia, Minggang Shi, Li-Man Hung, Jingsong Ruan, Tak Wah Mak, Qinxi Li, Jiahuai Han
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1846-1857 (2017)
2-hydroxyglutarate-(2-HG)-mediated inhibition of TET2 activity influences DNA hypermethylation in cells harboring mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2). Here, we show that 2-HG also regulates DNA methylation mediated by DNA methyltr
Externí odkaz:
https://doaj.org/article/5561e3556d15484aaec36954de27a045
Autor:
Bin Jiang, Jia Zhang, Jinmei Xia, Wentao Zhao, Yanan Wu, Minggang Shi, Lianzhong Luo, Huamin Zhou, Ai Chen, Huanhuan Ma, Qingwen Zhao, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Ying He, Xiaotong Li, Li-Man Hung, Tak Wah Mak, Qinxi Li
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 389-400 (2017)
Summary: Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and
Externí odkaz:
https://doaj.org/article/b80d34a1aa3942589bce34e3a3def92d
Autor:
Yu-Hao Liu, Chien-Chang Chen, Yi-Jen Hsueh, Li-Man Hung, David Hui-Kang Ma, Hung-Chi Chen, Wen-Bin Len, Yaa-Jyuhn J. Meir
Publikováno v:
Cells, Vol 10, Iss 2, p 284 (2021)
Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular e
Externí odkaz:
https://doaj.org/article/0cf14ebd65bd471aba8f1c74dee9b61d
Autor:
Chieh-Hua Lu, Po-Shiuan Hsieh, Yu-Feng Tian, Chao-Lan Yu, Feng-Chih Kuo, Pei-Chi Chan, Jiung-Pang Huang, Li-Man Hung, Yuan-Ji Day
Publikováno v:
Clinical Science. 136:121-137
Chemokine (C–C motif) ligand 5 (CCL5) and CCR5, one of its receptors have been reported to be highly expressed in white adipose tissue (WAT) and are associated with the progression of inflammation and the development of insulin resistance in obese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454337ba44f8a1b5f4abf3f2353405ad
https://doi.org/10.1042/cs20210959
https://doi.org/10.1042/cs20210959
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 46, p 46 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 46
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 46
International Journal of Molecular Sciences
The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b26b5625b2b5dc4de390e50c275f2a2
https://www.mdpi.com/1422-0067/23/1/46
https://www.mdpi.com/1422-0067/23/1/46
Autor:
Tzu-Chieh Liao, Jiung-Pang Huang, Yu-Ting Tsai, Wei-Ching Shih, Chi-Chang Juan, Po-Shiuan Hsieh, Li-Man Hung, Chao-Lan Yu
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13048
C-C chemokine receptor type 5 (CCR5) positively contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a common metabolic liver disease associated with chronic inflammation. CCR5 signaling also facilitates the immunosuppressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b12debadb7caaf471f05a3c29b095d9
Autor:
Mei-Ling Cheng, Fengqiong Zhang, Li-Man Hung, Shixiong Wen, Zhaoqianyu Xiong, Ming-Tong Tsau, Tingyan Cao, Yanming Zhou, Dachao Sun, Huanhuan Ma, Qinxi Li, Lin Zhou, Jinpei Zhu
Publikováno v:
Oncogene. 40:2567-2580
Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme in pentose phosphate pathway (PPP), excessive activation of which has been considered to be involved in tumorigenesis. Here, we show that tyrosine kinase c-Src interacts w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::631c1f0b9c4bfcc282e1f77539063d01
https://doi.org/10.1038/s41388-021-01673-0
https://doi.org/10.1038/s41388-021-01673-0