Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Li-Kun Phng"'
Autor:
Jianmin Yin, Niels Schellinx, Ludovico Maggi, Kathrin Gundel, Cora Wiesner, Maria Paraskevi Kotini, Minkyoung Lee, Li-Kun Phng, Heinz-Georg Belting, Markus Affolter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model, we develop a series of molecular reporters, photo-convertible an
Externí odkaz:
https://doaj.org/article/cac7d75bd81e4deaae5f1a4918d65a3d
Autor:
Swe Soe Maung Ye, Li-Kun Phng
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011665 (2023)
The development of a functional cardiovascular system ensures a sustainable oxygen, nutrient and hormone delivery system for successful embryonic development and homeostasis in adulthood. While early vessels are formed by biochemical signaling and ge
Externí odkaz:
https://doaj.org/article/5d7563d24453493ca876cd1f490d542f
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Mechanical forces from blood flow and pressure (hemodynamic forces) contribute to the formation and shaping of the blood vascular network during embryonic development. Previous studies have demonstrated that hemodynamic forces regulate signaling and
Externí odkaz:
https://doaj.org/article/3ffc7be1322b422cb5d4b954c98d64b6
Autor:
Igor Kondrychyn, Douglas J. Kelly, Núria Taberner Carretero, Akane Nomori, Kagayaki Kato, Jeronica Chong, Hiroyuki Nakajima, Satoru Okuda, Naoki Mochizuki, Li-Kun Phng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
During lumen formation in blood vessels, endothelial cells become exposed to hemodynamic forces that induce membrane blebbing and changes in cell shape. Here, the authors show endothelial cells develop an actin-based protective mechanism in the cell
Externí odkaz:
https://doaj.org/article/8be070b1e19849db983d903f0665e3ed
Autor:
Thomas Mathivet, Claire Bouleti, Matthias Van Woensel, Fabio Stanchi, Tina Verschuere, Li‐Kun Phng, Joost Dejaegher, Marly Balcer, Ken Matsumoto, Petya B Georgieva, Jochen Belmans, Raf Sciot, Christian Stockmann, Massimiliano Mazzone, Steven De Vleeschouwer, Holger Gerhardt
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 12, Pp 1629-1645 (2017)
Abstract Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia
Externí odkaz:
https://doaj.org/article/b3ac599960a14934a3bff514148fc011
Autor:
Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002163 (2015)
[This corrects the article DOI: 10.1371/journal.pbio.1002125.].
Externí odkaz:
https://doaj.org/article/8e2b316e4e87403b8eabbbaa558f2835
Autor:
Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002125 (2015)
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migr
Externí odkaz:
https://doaj.org/article/663453f3238d45cbb13917b0d72e3ea5
Autor:
Li-Kun Phng, Heinz-Georg Belting
Publikováno v:
Seminars in Cell & Developmental Biology. 120:32-43
The vertebrate cardiovascular system is made up by a hierarchically structured network of highly specialised blood vessels. This network emerges during early embryogenesis and evolves in size and complexity concomitant with embryonic growth and organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc1e0b14583ae547e6688f55a3d6160
https://doi.org/10.1016/j.semcdb.2021.06.005
https://doi.org/10.1016/j.semcdb.2021.06.005
Autor:
Swe Soe Maung Ye, Li-Kun Phng
The development of a functional cardiovascular system ensures successful embryonic development and a sustainable oxygen, nutrient and hormones delivery system for homeostasis in adulthood. While early vessels are formed by biochemical signaling and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63227a1d861fb5a57d8ae85ae86d39f
https://doi.org/10.1101/2022.12.07.519059
https://doi.org/10.1101/2022.12.07.519059
