Copy Number Analyses Identified a Novel Gene: APOBEC3A Related to Lipid Metabolism in the Pathogenesis of Preeclampsia

Autor: Nan Liu, Yu-Na Guo, Xiao-Jin Wang, Jue Ma, Yun-Ting He, Fang Zhang, Hao He, Jin-Liang Xie, Xu Zhuang, Meng Liu, Jian-Hua Sun, Yan Chen, Jian-Hua Lin, Li-Kun Gong, Bing-Shun Wang

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundPreeclampsia is a heterogeneous and complex disease with its pathogenesis mechanism not fully elucidated. A certain subset of patients with preeclampsia exhibit disturbances in lipid metabolism before clinical symptoms. Moreover, there is a

Externí odkaz: https://doaj.org/article/b1f02e3555d34f3da9dd70179adc837a

Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody

Autor: Xiao-Min, Jia, Yi-Ru, Long, Xiao-Lu, Yu, Run-Qiu, Chen, Li-Kun, Gong, Yong, Geng

Publikováno v: Acta Pharmacologica Sinica. 44:1095-1104

CKLF (chemokine-like factor)-MARVEL transmembrane domain containing protein 6 (CMTM6) is a novel regulator to maintain the stability of PD-L1. CMTM6 can colocalize and interact with PD-L1 on the recycling endosomes and cell membrane, preventing PD-L1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4278440acc0d7fc24ec37c11176cbc5f
https://doi.org/10.1038/s41401-022-01020-3

Advances in biomarker development and potential application for preeclampsia based on pathogenesis

Autor: Bing-Shun Wang, Li-Kun Gong, Nan Liu, Yu-Na Guo

Publikováno v: European Journal of Obstetrics & Gynecology and Reproductive Biology: X
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, Vol 9, Iss, Pp 100119-(2021)

Preeclampsia (PE) is a pregnancy-specific complication that seriously threatens the health and safety of mothers and infants. The etiology of PE has not been fully elucidated, and no effective treatments are currently available. A pregnant woman with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5995b257f78c71f6d405f21c9de75016
https://doi.org/10.1016/j.eurox.2020.100119

[Progress of the study of mechanism on drug induced kidney injury]

Autor: Xiang, Xue, Li-kun, Gong, Jin, Ren

Publikováno v: Yao xue xue bao = Acta pharmaceutica Sinica. 45(10)

Drug-induced nephrotoxicity is very common in both new drug development and clinic practice. Various drugs can induce kidney injuries, including tubulointerstitial, glomerular and renal vascular disease. To investigate the mechanism of drug induced n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6810bc7c06755881382daf6128cbb6f
https://pubmed.ncbi.nlm.nih.gov/21348296

β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.

Autor: Ying XIAO, Xiang XUE, Yuan-feng WU, Guo-zheng XIN, Yong QIAN, Tian-pei XIE, Li-kun GONG, Jin REN

Publikováno v: Acta Pharmacologica Sinica; Nov2009, Vol. 30 Issue 11, p1559-1565, 7p, 2 Color Photographs, 2 Charts, 4 Graphs