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MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5

Autor: Xiao-Xiao Yang, Zhou-Ya Xue, Li-Jiao Zhu, Meng-Lan Sun, Zhiqiang Pan, Ming Zhang, Di Liu, Li Guofang, Ling Xie, Huimin Zhou, Qi Zhang, Xiaodan Liu, Jun-Li Cao, Sun-Hui Xia, Ling-Yun Hao

Publikováno v: The Journal of Neuroscience. 39:2125-2143

Dysfunctions of gene transcription and translation in the nociceptive pathways play the critical role in development and maintenance of chronic pain. Circular RNAs (circRNAs) are emerging as new players in regulation of gene expression, but whether a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250a2a0728c6a06b480ee706497a59c1
https://doi.org/10.1523/jneurosci.1631-18.2018

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DNA Hydroxymethylation by Ten-eleven Translocation Methylcytosine Dioxygenase 1 and 3 Regulates Nociceptive Sensitization in a Chronic Inflammatory Pain Model

Autor: Zhiqiang Pan, Ming Zhang, Qian-Qian Tang, Meng-Lan Sun, Li Guofang, Ling-Yun Hao, Jun-Li Cao, Li-Jiao Zhu, Zhou-Ya Xue

Publikováno v: Anesthesiology. 127(1)

Background Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b15babfcba1de2f7d5d6d84f1bb3b9
https://pubmed.ncbi.nlm.nih.gov/28437360

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Energy-Efficient Rings: A Green Mechanism for Multi-Segment Fiber-Wireless Access Networks

Autor: Wei Gong Hou, Lei Guo, Xiao Xue Gong, Ye Jun Liu, Li Jiao Zhu

Publikováno v: Applied Mechanics and Materials. :2451-2454

In this paper, we propose a novel green mechanism called Energy-Efficient Ring (EER) for multi-segment Fiber-Wireless (FiWi) access networks. We first utilize clustering scheme to generate clusters each with the shortest distance of fully connected s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b769fdf501798aeb9059b2e823b930cc
https://doi.org/10.4028/www.scientific.net/amm.336-338.2451

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Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2

Autor: Zhiqiang Pan, Li-Jiao Zhu, Ling-Yun Hao, Hai-Lei Ding, Yan-Qiang Li, Tao Ma, Zhou-Ya Xue, Jun-Li Cao, Ming Zhang, Li Guofang

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(9)

DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, thein vivocausal link between TET dysregulation and nociceptive modulation has not been estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64263b3551e4fcd38dd3bd720a2c9aa5
https://pubmed.ncbi.nlm.nih.gov/26937014

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Epigenetic Modification of Spinal miR-219 Expression Regulates Chronic Inflammation Pain by Targeting CaMKIIγ

Autor: Jun-Xia Yang, Cui Yin, Zhiqiang Pan, Yan-Qiang Li, Zhou-Ya Xue, Hongxing Zhang, Song Zhang, Ling-Yun Hao, Yubai Guo, Lu Hua, Jun-Li Cao, Li-Jiao Zhu

Emerging evidence has shown that miRNA-mediated gene expression modulation contributes to chronic pain, but its functional regulatory mechanism remains unknown. Here, we found that complete Freund's adjuvant (CFA)-induced chronic inflammation pain si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fb505440e6a9f126feb258c3798141
https://europepmc.org/articles/PMC6608325/