Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Li-Fong Seet"'
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Peripheral iridectomy (PI), routinely performed during glaucoma filtration surgery, may contribute to scarring. This study aims to determine whether PI alters the concentrations of VEGF-A and TGF-β isoforms in the rabbit aqueous
Externí odkaz:
https://doaj.org/article/92c25db14bd14c79b847de97cddc8767
Autor:
Li-Fong Seet, Li Zhen Toh, Stephanie W. L. Chu, Sharon N. Finger, Jocelyn L. L. Chua, Tina T. Wong
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 751-760 (2017)
Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma filtration surgery (GFS). Using the mouse model of GFS, we h
Externí odkaz:
https://doaj.org/article/68c4ca46b7c44731b39d17441d4b0720
Autor:
Li-Fong Seet, Roseline Su, V A Barathi, Wing Sum Lee, Rebekah Poh, Yee Meng Heng, Ed Manser, Eranga N Vithana, Tin Aung, Matt Weaver, E Helene Sage, Tina T Wong
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9415 (2010)
Glaucoma is a disease frequently associated with elevated intraocular pressure that can be alleviated by filtration surgery. However, the post-operative subconjunctival scarring response which blocks filtration efficiency is a major hurdle to the ach
Externí odkaz:
https://doaj.org/article/e93f3dfc7c0d46fe9a9bcea67ed39746
Autor:
Li-Fong Seet, Zhu Li Yap, Stephanie W. L. Chu, Li Zhen Toh, Farah Ilyana Ibrahim, Xiao Teng, Tina T. Wong
Publikováno v:
Translational Vision Science & Technology
Purpose This study aimed to compare the effectiveness of combination therapy consisting of low-dose mitomycin C (MMC) and valproic acid (VPA) against high-dose MMC for improving the scar phenotype in minimally invasive glaucoma surgery (MIGS). Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5b40310aa40300043ef58ce4dfbad6
http://europepmc.org/articles/PMC8787605
http://europepmc.org/articles/PMC8787605
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 100(6)
Valproic acid (VPA), widely used for the treatment of neurological disorders, has anti-fibrotic activity by reducing collagen production in the postoperative conjunctiva. In this study, we investigated the capacity of VPA to modulate the postoperativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9709c1952c699521725a6988ae181e28
https://pubmed.ncbi.nlm.nih.gov/35583819
https://pubmed.ncbi.nlm.nih.gov/35583819
Publikováno v:
Ocular Immunology and Inflammation. 29:29-42
Purpose: This study investigated the involvement of NF-kB in regulating postoperative conjunctival inflammation.Methods: Experimental surgery was performed as described for the mouse model of conjunctival scarring. Expression of NF-κB in postoperati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549cd2bf7436247d9b6a115862b18002
https://doi.org/10.1080/09273948.2019.1662060
https://doi.org/10.1080/09273948.2019.1662060
Autor:
Zhu Li Yap, Li-Fong Seet, Chu, Stephanie W. L., Li Zhen Toh, Ibrahim, Farah Ilyana, Wong, Tina T.
Publikováno v:
British Journal of Ophthalmology; Jul2022, Vol. 106 Issue 7, p1028-1036, 9p
Publikováno v:
The British journal of ophthalmology. 106(7)
PurposeTo determine the effect of valproic acid (VPA) on bleb morphology and scar characteristics in a rabbit model of minimally invasive glaucoma surgery (MIGS).MethodsNine New Zealand white rabbits were subjected to MIGS with intraoperative implant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a80ee5485ae5f770a820533ff20b2e
https://pubmed.ncbi.nlm.nih.gov/34266858
https://pubmed.ncbi.nlm.nih.gov/34266858
Autor:
Li-Fong Seet, Zhu Li Yap, Tina T. Wong, Stephanie Chu, Hiok Hong Chan, Yong Yao Chun, Timothy Thatt Yang Tan, Li Zhen Toh, Ying Shi Lee
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment. Here, a biocompatible injectable gelatin-based h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42283d987287f3b99104d97682bed936
https://pubmed.ncbi.nlm.nih.gov/33446775
https://pubmed.ncbi.nlm.nih.gov/33446775
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e979e0f8a9935137f47197a97c82f0c
http://europepmc.org/articles/PMC6326969
http://europepmc.org/articles/PMC6326969