Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Li-Fan Zeng"'
Autor:
Zhong-Yin Zhang, Sheng Zhang, Li-Fan Zeng, Ruo-Yu Zhang, Lujuan Zhang, Sijiu Liu, Zhi-Hong Yu, Yunpeng Bai
Supplemental information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae52600b438b15efc1746c468e964015
https://doi.org/10.1158/0008-5472.22402754.v1
https://doi.org/10.1158/0008-5472.22402754.v1
Autor:
Emily Sun, Melissa L. Fishel, Ahmad R. Safa, Zhong Yin Zhang, Jessica Mo, Özlem Demir, Rommie E. Amaro, Murray Korc, Han Wei, John Wang, Li-Fan Zeng, Lakshmi Prabhu, Tao Lu, George E. Sandusky, Lan Chen
Publikováno v:
Oncotarget
Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive nuclear factor κB (NF-κB) is a common culprit in both cancers. Previously, we discovered that protein arginine methyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1195d1b5549fed4ab9bfda60f8c07fe
https://doi.org/10.18632/oncotarget.18102
https://doi.org/10.18632/oncotarget.18102
Autor:
Han Wei, Özlem Demir, Zhon Yin Zhang, Tao Lu, Rommie E. Amaro, Bert H. O'Neil, Lan Chen, Ahmad R. Safa, Li-Fan Zeng, Lakshmi Prabhu
Publikováno v:
Molecular BioSystems. 13:2509-2520
The protein arginine methyltransferase (PRMT) family of enzymes comprises nine family members in mammals. They catalyze arginine methylation, either monomethylation or symmetric/asymmetric dimethylation of histone and non-histone proteins. PRMT methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c98a616432c31e6559dbeacb498c4b
https://doi.org/10.1039/c7mb00391a
https://doi.org/10.1039/c7mb00391a
Autor:
Sheng Zhang, Sijiu Liu, Ruo-Yu Zhang, Lujuan Zhang, Li-Fan Zeng, Zhong Yin Zhang, Zhi-Hong Yu, Yunpeng Bai
Publikováno v:
Cancer Research. 76:4805-4815
Phosphatase of regenerating liver (PRL) oncoproteins are phosphatases overexpressed in numerous types of human cancer. Elevated levels of PRL associate with metastasis and poor clinical outcomes. In principle, PRL phosphatases offer appealing therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b077db53d6255f4338efd0df7a4b0000
https://doi.org/10.1158/0008-5472.can-15-2323
https://doi.org/10.1158/0008-5472.can-15-2323
Autor:
Li-Fan Zeng, Li Wu, Zhi-Hong Yu, Jun O. Liu, Andrea M. Gunawan, Zhong Yin Zhang, Joong Sup Shim, Brandon S. Lane, Lan Chen, Yantao He, Clark D. Wells, Ruo-Yu Zhang, Rongjun He
Publikováno v:
ACS Medicinal Chemistry Letters. 6:782-786
Protein tyrosine phosphatases (PTPs) are potential therapeutic targets for many diseases. Unfortunately, despite considerable drug discovery efforts devoted to PTPs, obtaining selective and cell permeable PTP inhibitors remains highly challenging. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8fa162845bec1f83866932e7d435d8
https://doi.org/10.1021/acsmedchemlett.5b00118
https://doi.org/10.1021/acsmedchemlett.5b00118
Publikováno v:
Circulation. 136
Introduction: Systemic lupus erythematous (SLE) is a devastating autoimmune disorder affecting multiple tissues, including heart. However, the molecular mechanisms that cause cardiac effects in SLE remain unclear. PTPN11 , the gene encoding the SH2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f0a8c607b239211ad9ca81c4a1f1c03
https://doi.org/10.1161/circ.136.suppl_1.20959
https://doi.org/10.1161/circ.136.suppl_1.20959
Autor:
Stephanie Everingham, Namit Sharma, Zhong Yin Zhang, Reuben Kapur, Andrew W.B. Craig, Li-Fan Zeng
Publikováno v:
Oncotarget
Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751e0cda02f9742b220b13f651c654b0
https://doi.org/10.18632/oncotarget.2177
https://doi.org/10.18632/oncotarget.2177
Publikováno v:
ChemMedChem. 8:904-908
A facile hydroxyindole carboxylic acid-based focused amide library approach was designed to target both the PTP active site and a unique nearby pocket for enhanced affinity and selectivity. High throughput screening of the focused library let to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd8d224ae6fb19b82b821125707f868
https://doi.org/10.1002/cmdc.201300115
https://doi.org/10.1002/cmdc.201300115
Autor:
Zhong Yin Zhang, Jinmin Miao, Ruo-Yu Zhang, Sheng Zhang, Li-Fan Zeng, Zhi-Hong Yu, Jingwu Xie, Yunpeng Bai, Lan Chen
Publikováno v:
Oncotarget
Melanoma ranks among the most aggressive and deadly human cancers. Although a number of targeted therapies are available, they are effective only in a subset of patients and the emergence of drug resistance often reduces durable responses. Thus there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28f9ddf69c225277685e459c5fa4ecc
https://pubmed.ncbi.nlm.nih.gov/27650545
https://pubmed.ncbi.nlm.nih.gov/27650545
Autor:
Roderick T. Bronson, Michele Finnell, Li-Fan Zeng, Maria I. Kontaridis, Vasileios C. Kyttaris, George C. Tsokos, Jianxun Wang, Zhong Yin Zhang, Cox Terhorst, Masayuki Mizui
Publikováno v:
The Journal of clinical investigation. 126(6)
Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder predominantly caused by gai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4272b239f2f996e4b70f3d226711b3b0
https://pubmed.ncbi.nlm.nih.gov/27256710
https://pubmed.ncbi.nlm.nih.gov/27256710