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Akademický článek

Hsa‐miR‐335 enhances cell migration and invasion in lung adenocarcinoma through targeting Copine‐1

Autor: Yang Wang, Jing Zhang, Li‐Ye Zhong, Shang‐Jia Huang, Nan‐Nan Yu, Lan Ouyang, Yu‐Long Niu, Jun‐Xiong Chen, Chun‐Hua Lu, Qing‐Yu He

Publikováno v: MedComm, Vol 2, Iss 4, Pp 810-820 (2021)

Abstract Lung adenocarcinoma (LAC) is one of the most common pulmonary adenocarcinomas with a high peak of mortality, and metastasis is the main culprit of LAC deaths. microRNAs play important role in cancer metastasis, and thus are regarded as poten

Externí odkaz: https://doaj.org/article/93241986d59c49769a58b075b9046509

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Akademický článek

Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma

Autor: Miao Li, Lin Qi, Jing-Bo Xu, Li-Ye Zhong, Szehoi Chan, Shu-Na Chen, Xin-Rong Shao, Li-Yuan Zheng, Zhao-Xia Dong, Tian-Liang Fang, Zhi-Ying Mai, Juan Li, Yongjiang Zheng, Xing-Ding Zhang

Publikováno v: Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 197-207 (2020)

The molecular alterations that initiate the development of multiple myeloma (MM) are not fully understood. Our results revealed that TJP1 was downregulated in MM and positively related to the overall survival of MM patients in The Cancer Genome Atlas

Externí odkaz: https://doaj.org/article/0cde850ecbae4c058346be646d839239

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Akademický článek

Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth

Autor: Jing Zhang, Yue Sun, Li-Ye Zhong, Nan-Nan Yu, Lan Ouyang, Run-Dong Fang, Yang Wang, Qing-Yu He

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3936-3946 (2020)

Rab5 is a small GTPase that plays a crucial role in oncogenic signal transduction, which was considered as an attractive target for cancer therapy. Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progressi

Externí odkaz: https://doaj.org/article/f616b6af42194681812d38aca604baa3

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Akademický článek

Comparative Proteome Identifies Complement Component 3-Mediated Immune Response as Key Difference of Colon Adenocarcinoma and Rectal Adenocarcinoma

Autor: Jun-Ze Liang, Xiao-Ling Liang, Li-Ye Zhong, Chu-Tian Wu, Jing Zhang, Yang Wang

Publikováno v: Frontiers in Oncology, Vol 10 (2021)

Colorectal cancer (CRC) is one of the most lethal diseases with high morbidity and mortality worldwide. Clinically, tumors located in colon and rectum have diverse prognosis and therapeutic outcome. Here, we performed data mining derived from 20 CRC

Externí odkaz: https://doaj.org/article/65bd769f6239432ba32e81a29262cc32

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