Výsledky vyhledávání - "Li Sheng Fowler"

EnhancedIn VitroandIn VivoPotency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Autor: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A. Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P. Weir, Keith Peden, Marian E. Major

Publikováno v: J Virol

Studies on Ebola virus disease (EVD) survivors and clinical studies on Ebola virus (EBOV) vaccine candidates have pinpointed the importance of a strong antibody response in protection and survival from EBOV infection. However, little is known about t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12828c13a03f3cdeed407a785ee4dc39
https://doi.org/10.1128/jvi.01166-21

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Akademický článek

Tumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both Activated H-ras and c-myc

Autor: Li Sheng-Fowler, Fang Cai, Haiqing Fu, Yong Zhu, Brian Orrison, Gideon Foseh, Don G. Blair, Stephen H. Hughes, John M. Coffin, Andrew M. Lewis Jr, Keith Peden

Publikováno v: International Journal of Biological Sciences, Vol 6, Iss 2, Pp 151-162 (2010)

Vaccines contain residual DNA derived from the cells used to produce them. As part of our investigation to assess the risk of this cellular DNA, we are developing a quantitative in vivo assay to assess the oncogenicity of DNA. In an earlier study, we

Externí odkaz: https://doaj.org/article/58b56bd271b2476b8c04aab41af6049b

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Akademický článek

A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.

Autor: Li Sheng-Fowler, Wei Tu, Haiqing Fu, Haruhiko Murata, Lynda Lanning, Gideon Foseh, Juliete Macauley, Donald Blair, Stephen H Hughes, John M Coffin, Andrew M Lewis, Keith Peden

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108926 (2014)

As part of safety studies to evaluate the risk of residual cellular DNA in vaccines manufactured in tumorigenic cells, we have been developing in vivo assays to detect and quantify the oncogenic activity of DNA. We generated a plasmid expressing both

Externí odkaz: https://doaj.org/article/3c8dc40e48fe42a784ed002171f4f82d

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Development of a micro-neutralization assay for ebolaviruses using a replication-competent vesicular stomatitis hybrid virus and a quantitative PCR readout

Autor: Kathryn Phy, Stella S. Lee, Li Sheng-Fowler, Keith Peden

Publikováno v: Vaccine. 35(41)

Development of vaccines against highly pathogenic viruses that could also be used as agents of bioterrorism is both a public health issue and a national security priority. Methods that can quantify neutralizing antibodies will likely be crucial in de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec82ac3d9bc817b69cb2dbfe21bd5dad
https://pubmed.ncbi.nlm.nih.gov/28427845

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Tumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both Activated H-ras and c-myc

Autor: Stephen H. Hughes, Yong Zhu, Haiqing Fu, Gideon Foseh, Li Sheng-Fowler, Keith Peden, Fang Cai, Don G. Blair, Brian Orrison, John M. Coffin, Andrew M. Lewis

Publikováno v: International Journal of Biological Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd1946a05f159a471bdf12e55d4a719
https://doi.org/10.7150/ijbs.6.151

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A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc

Autor: Donald G. Blair, Li Sheng-Fowler, Juliete Macauley, Haiqing Fu, Haruhiko Murata, Stephen H. Hughes, Keith Peden, Lynda L Lanning, John M. Coffin, Andrew M. Lewis, Wei Tu, Gideon Foseh

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108926 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835a4e9731fc118e554f4a1c86474cb7
http://europepmc.org/articles/PMC4193875?pdf=render

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Quantitative determination of the infectivity of the proviral DNA of a retrovirus in vitro: Evaluation of methods for DNA inactivation

Autor: Andrew M. Lewis, Keith Peden, Li Sheng-Fowler

Publikováno v: Biologicals : journal of the International Association of Biological Standardization. 37(4)

All viral vaccines contain contaminating residual DNA derived from the production cell substrate. The potential risk of this DNA, particularly when derived from tumorigenic cells, has been debated for over 40 years. While the major risk has been cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed8fdb04788d6b2d7f0b749f52ed9c4
https://pubmed.ncbi.nlm.nih.gov/19457682

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Akademický článek

Enhanced In Vitro and In Vivo Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions.

Autor: Chabot, Sylvie¹, Gimie, Yusra¹, Obeid, Karam¹, Kim, Jaekwan¹, Meseda, Clement A.¹, Konduru, Krishnamurthy², Kaplan, Gerardo², Li Sheng Fowler¹, Weir, Jerry P.¹, Peden, Keith¹, Major, Marian E.¹ marian.major@fda.hhs.gov

Publikováno v: Journal of Virology. 9/15/2022, Vol. 96 Issue 18, p1-13. 13p.

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