Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Li Ren Kong"'
Autor:
Cherif Badja, Sophie Momen, Gene Ching Chiek Koh, Soraya Boushaki, Theodoros I. Roumeliotis, Zuza Kozik, Ian Jones, Vicky Bousgouni, João M.L. Dias, Marios G. Krokidis, Jamie Young, Hongwei Chen, Ming Yang, France Docquier, Yasin Memari, Lorea Valcarcel-Zimenez, Komal Gupta, Li Ren Kong, Heather Fawcett, Florian Robert, Salome Zhao, Andrea Degasperi, Yogesh Kumar, Helen Davies, Rebecca Harris, Christian Frezza, Chryssostomos Chatgilialoglu, Robert Sarkany, Alan Lehmann, Chris Bakal, Jyoti Choudhary, Hiva Fassihi, Serena Nik-Zainal
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114243- (2024)
Summary: Xeroderma pigmentosum (XP) is caused by defective nucleotide excision repair of DNA damage. This results in hypersensitivity to ultraviolet light and increased skin cancer risk, as sunlight-induced photoproducts remain unrepaired. However, m
Externí odkaz:
https://doaj.org/article/3afcfcc423e04f808db8a71c2cb5d72f
Autor:
Maryam Ghaderi Najafabadi, G. Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S. Brugge, Ashok R. Venkitaraman, Mona Shehata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2 mut/WT mammary organoids subjected t
Externí odkaz:
https://doaj.org/article/f836acac45844291bd635b3b1255cb55
Autor:
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-ass
Externí odkaz:
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
Autor:
Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, Miyoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregul
Externí odkaz:
https://doaj.org/article/89ea4992ac4f465ea6d7ca0e0a05a0dd
Autor:
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L. Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel S. W. Tan, N. Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S. Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline S. J. Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H. Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancer
Externí odkaz:
https://doaj.org/article/29d0a642abdc45549ef07f126485d155
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101834- (2021)
Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector
Externí odkaz:
https://doaj.org/article/aba2011be1854a19a8dda0caeeb71275
Autor:
Jayshree Hirpara, Jie Qing Eu, Joanna Kia Min Tan, Andrea L. Wong, Marie-Veronique Clement, Li Ren Kong, Naoto Ohi, Takeshi Tsunoda, Jianhua Qu, Boon Cher Goh, Shazib Pervaiz
Publikováno v:
Redox Biology, Vol 25, Iss , Pp - (2019)
The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regi
Externí odkaz:
https://doaj.org/article/d46da55d48664a19ac1a67dc7607df13
Autor:
Jiaqi Li, Jie Qing Eu, Li Ren Kong, Lingzhi Wang, Yaw Chyn Lim, Boon Cher Goh, Andrea L. A. Wong
Publikováno v:
Molecules, Vol 25, Iss 20, p 4831 (2020)
Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may b
Externí odkaz:
https://doaj.org/article/fa8f63fe72d24b51a0510ea9aec3d75e
Autor:
Chang Cheng, W Eugene Ho, Fera Y Goh, Shou Ping Guan, Li Ren Kong, Wen-Qi Lai, Bernard P Leung, W S Fred Wong
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20932 (2011)
BACKGROUND: Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua, and has
Externí odkaz:
https://doaj.org/article/97583af4ba884750a84169648efc068e
Autor:
Win Lwin Thuya, Li Ren Kong, Nicholas L. Syn, Ling-Wen Ding, Esther Sok Hwee Cheow, Regina Tong Xin Wong, Tingting Wang, Robby Miguel Wen-Jing Goh, Hongyan Song, Migara K. Jayasinghe, Minh TN Le, Jian Cheng Hu, Wei-Peng Yong, Soo-Chin Lee, Andrea Li-Ann Wong, Gautam Sethi, Huynh The Hung, Paul Chi-Lui Ho, Jean-Paul Thiery, Siu Kwan Sze, Tiannan Guo, Ross A. Soo, Henry Yang, Yaw Chyn Lim, Lingzhi Wang, Boon-Cher Goh
Publikováno v:
Theranostics. 13:621-638