Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Li Ming Lim"'
Autor:
Rathi Saravanan, Yeu Khai Choong, Chun Hwee Lim, Li Ming Lim, Jitka Petrlova, Artur Schmidtchen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial proteins and peptides bound to cfDNA play a critical role in the bactericidal property of NETs. Re
Externí odkaz:
https://doaj.org/article/39d9d73a3e00424890ea3fba1b78ee7e
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 979 (2022)
Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-established solubility enhancement strategy for poorly soluble drugs. Recently, two amorphous drug formulations, i.e., the amorphous drug–polyelectrolyte na
Externí odkaz:
https://doaj.org/article/45cccc76769444049625de032ca19903
Autor:
Li Ming Lim, Kunn Hadinoto
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9399 (2021)
Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue o
Externí odkaz:
https://doaj.org/article/7b19a14c9228428784a752b000c7ced2
Autor:
Kunn Hadinoto, Li Ming Lim
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9399, p 9399 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences
Volume 22
Issue 17
Oral delivery of curcumin (CUR) has limited effectiveness due to CUR's poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346d071426c09c7c006787404bb6aa2f
https://www.mdpi.com/1422-0067/22/17/9399
https://www.mdpi.com/1422-0067/22/17/9399
Publikováno v:
European Journal of Pharmaceutical Sciences. 114:356-363
The numerous health benefits of curcumin (CUR) have not been fully realized due to its low aqueous solubility, resulting in poor bioavailability. While amorphization of CUR via amorphous solid dispersion (ASD) represents a well-established CUR solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4dfcc0481a49d077288f441747c8a0
https://doi.org/10.1016/j.ejps.2018.01.010
https://doi.org/10.1016/j.ejps.2018.01.010
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:455-463
The solubility enhancement afforded by amorphous drug nanoparticles was demonstrated in several studies to be superior to the traditional amorphization approach by microscale amorphous solid dispersion (or micro ASD in short). A closer look at these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becc457c3e65f31306ada61cd127d045
https://doi.org/10.1016/j.ejps.2017.09.010
https://doi.org/10.1016/j.ejps.2017.09.010
Autor:
Li Ming Lim, Kunn Hadinoto
Publikováno v:
International Journal of Pharmaceutics. 575:119007
While the solubility enhancement capability of amorphous drug-polyelectrolyte nanoparticle complex (nanoplex) has been widely established, its amorphous form stability during long-term storage is often lacking for poorly-soluble drugs with high cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d0a5b96600b446a3d82c9d88f1c5c3
https://doi.org/10.1016/j.ijpharm.2019.119007
https://doi.org/10.1016/j.ijpharm.2019.119007
Autor:
Kunn Hadinoto, Wean Sin Cheow, Jerome Jie Long Wong, Li Ming Lim, Danping Wang, The-Thien Tran
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 167
The low aqueous solubility of curcumin (CUR) had greatly limited the clinical efficacy of CUR therapy despite its well-known potent therapeutic activities. Previously, we developed amorphous nanoparticle complex (nanoplex) of CUR and chitosan (CHI) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7510bd6692705c88131ba8f4be664b19
https://pubmed.ncbi.nlm.nih.gov/29727835
https://pubmed.ncbi.nlm.nih.gov/29727835
Objectives: To carry out a proof-of-concept study on the development of dual-drug amorphous nanoparticle complex (nanoplex in short) as a potential formulation platform for fixed-dose combination (FDC) of poorly-soluble drugs. Significance: FDC has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b679701e9a5281baf4a2bd60cb65f510
Publikováno v:
European Journal of Pharmaceutical Sciences. 138:105035
Amorphous drug-polyelectrolyte nanoparticle complex (or nanoplex in short) has emerged as a highly attractive solubility enhancement strategy of poorly-soluble drugs attributed to its simple and highly efficient preparation. The existing nanoplex for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f707f41c3e9680be9eaeaee93235d9
https://doi.org/10.1016/j.ejps.2019.105035
https://doi.org/10.1016/j.ejps.2019.105035