Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Li Ming Gan"'
Autor:
Sven O. Göpel, Damilola Adingupu, Jue Wang, Elizaveta Semenova, Margareta Behrendt, Rasmus Jansson-Löfmark, Christine Ahlström, Ann-Cathrine Jönsson-Rylander, V. Sashi Gopaul, Russell Esterline, Li-Ming Gan, Rui-Ping Xiao
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background SGLT2 inhibitors, a T2DM medication to lower blood glucose, markedly improve cardiovascular outcomes but the underlying mechanism(s) are not fully understood. SGLT2i’s produce a unique metabolic pattern by lowering blood glucose
Externí odkaz:
https://doaj.org/article/e4b485641d78496b9714711ae24f8c10
Autor:
Mikael Erhardsson, Ulrika Ljung Faxén, Ashwin Venkateshvaran, Sara Svedlund, Antti Saraste, Maria Lagerström Fermer, Li‐Ming Gan, Sanjiv J. Shah, Jasper Tromp, Carolyn SP Lam, Lars H. Lund, Camilla Hage
Publikováno v:
ESC Heart Failure, Vol 10, Iss 6, Pp 3729-3734 (2023)
Abstract Aims In heart failure with preserved ejection fraction (HFpEF), regional heterogeneity of clinical phenotypes is increasingly recognized, with coronary microvascular dysfunction (CMD) potentially being a common shared feature. We sought to d
Externí odkaz:
https://doaj.org/article/ecc5c1aa1c69414aa8ddc535bc0acc20
Autor:
Connor Siggins, Jonathan A. Pan, Adrián I. Löffler, Yang Yang, Peter W. Shaw, Pelbreton C. Balfour, Frederick H. Epstein, Li-Ming Gan, Christopher M. Kramer, Ellen C. Keeley, Michael Salerno
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
IntroductionHeart failure with preserved ejection fraction (HFpEF) is a complex disease process influenced by metabolic disorders, systemic inflammation, myocardial fibrosis, and microvascular dysfunction. The goal of our study is to identify potenti
Externí odkaz:
https://doaj.org/article/cb6042fc94eb44619d7b07b3e371eefd
Autor:
Truls Råmunddal, Christian Dworeck, Petronella Torild, Sofie Andréen, Li-Ming Gan, Geir Hirlekar, Dan Ioanes, Anna Myredal, Jacob Odenstedt, Petur Petursson, Tetiana Pylova, Fanny Töpel, Sebastian Völz, Mats Hilmersson, Björn Redfors, Oskar Angerås
Publikováno v:
Cardiology Research and Practice, Vol 2024 (2024)
Background. Using a fluid-filled wire with a pressure sensor outside the patient compared to a conventional pressure wire may avoid the systematic error introduced by the hydrostatic pressure within the coronary circulation. Aims. To assess the safet
Externí odkaz:
https://doaj.org/article/0f6668a04a2343c694834a1c96f108b0
Autor:
Alexis Hofherr, Julie Williams, Li-Ming Gan, Magnus Söderberg, Pernille B. L. Hansen, Kevin J. Woollard
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Mortality and morbidity associated with DKD are increasing with the global prevalence of type 2 diabetes. Chronic, sub-clinical, non-resolving inflammation contr
Externí odkaz:
https://doaj.org/article/441494f4155e41ac8b207d9608db287a
Autor:
Anwar Ali, Björn Redfors, Jessica Alkhoury, Jonatan Oras, Marcus Henricsson, Jan Boren, Elias Björnson, Aaron Espinosa, Malin Levin, Li‐Ming Gan, Elmir Omerovic
Publikováno v:
ESC Heart Failure, Vol 8, Iss 5, Pp 4130-4138 (2021)
Abstract Aims Takotsubo syndrome (TTS) is an acute potentially reversible cardiac syndrome characterized by variable regional myocardial akinesia that cannot be attributed to a culprit coronary artery occlusion. TTS is an important differential diagn
Externí odkaz:
https://doaj.org/article/a0476fe931184582a69f393cf4554398
Autor:
Karin Nelander, Maria Lagerstrom‐Fermer, Carl Amilon, Erik Michaëlsson, Maria Heijer, Magnus Kjaer, Muir Russell, David Han, Eva‐Lotte Lindstedt, Carl Whatling, Li‐Ming Gan, Hans Ericsson
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 812-819 (2021)
We evaluated safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics of AZD4831, a novel oral myeloperoxidase (MPO) inhibitor, in a randomized, single‐blind, placebo‐controlled study, following once‐daily multiple ascending dosing to
Externí odkaz:
https://doaj.org/article/56e9be1d8c7f4c148612b0396fe35f83
Autor:
Ravi B. Patel, Carolyn S. P. Lam, Sara Svedlund, Antti Saraste, Camilla Hage, Ru-San Tan, Lauren Beussink-Nelson, Jasper Tromp, Cynthia Sanchez, Joyce Njoroge, Stanley A. Swat, Ulrika Ljung Faxén, Maria Lagerstrom Fermer, Ashwin Venkateshvaran, Li-Ming Gan, Lars H. Lund, Sanjiv J. Shah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Impaired left atrial (LA) function in heart failure with preserved ejection fraction (HFpEF) is associated with adverse outcomes. A subgroup of HFpEF may have LA myopathy out of proportion to left ventricular (LV) dysfunction; therefore, we
Externí odkaz:
https://doaj.org/article/e093b432c8384f01a9adf34cc50f376f
Autor:
Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucos
Externí odkaz:
https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
Autor:
Anwar Ali, Björn Redfors, Joel Lundgren, Jessica Alkhoury, Jonatan Oras, Li‐Ming Gan, Elmir Omerovic
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2690-2699 (2020)
Abstract Aims Takotsubo syndrome (TS) is an acute cardiac syndrome characterized by regional myocardial akinesia that cannot be attributed to a culprit lesion in coronary arteries. Cardiac overstimulation by catecholamines in the setting of stress is
Externí odkaz:
https://doaj.org/article/913ee3fac37340d59d575926be7f6b9f