Výsledky vyhledávání - "Li Juan Song"

Akademický článek

The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer’s disease

Autor: Yi-Ge Wu, Li-Juan Song, Li-Jun Yin, Jun-Jun Yin, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma

Publikováno v: Neural Regeneration Research, Vol 18, Iss 5, Pp 947-954 (2023)

Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes; these events hav

Externí odkaz: https://doaj.org/article/18c64338d9554fcb894d54c0f2a682c4

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Akademický článek

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

Autor: Qing Wang, Li-Juan Song, Zhi-Bin Ding, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma

Publikováno v: Neural Regeneration Research, Vol 17, Iss 12, Pp 2623-2631 (2022)

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase family, which plays a pivotal role in regulating the damage, survival, axon guidance, and regeneration of neurons. ROCKs are also involved in the biological effects of

Externí odkaz: https://doaj.org/article/8fde7ae105ca49a4b5499c0613b60fd5

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Akademický článek

Astrocytes: a double-edged sword in neurodegenerative diseases

Autor: Zhi-Bin Ding, Li-Juan Song, Qing Wang, Gajendra Kumar, Yu-Qing Yan, Cun-Gen Ma

Publikováno v: Neural Regeneration Research, Vol 16, Iss 9, Pp 1702-1710 (2021)

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects. Astrocytes become activated as a

Externí odkaz: https://doaj.org/article/76c272200a444dbea983f699d6e66db1

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Akademický článek

Fasudil reduces β-amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice via inhibition of the Nogo-A/NgR/RhoA signaling axis

Autor: Min-Fang Guo, Hui-Yu Zhang, Pei-Jun Zhang, Xiao-Qin Liu, Li-Juan Song, Wen-Yue Wei, Yu-Yin Wang, Bing-Tao Mu, Zhi Chai, Jie-Zhong Yu, Cun-Gen Ma

Publikováno v: Journal of Integrative Neuroscience, Vol 19, Iss 4, Pp 651-662 (2020)

Recent studies have shown that Nogo-A and the Nogo-A receptor affect β-amyloid metabolism and the downstream Rho GTP enzyme signaling pathway, which may affect the levels of β-amyloid and tau. Nogo-A may play a key role in the pathogenesis of Alzhe

Externí odkaz: https://doaj.org/article/79a592c5223f4068bd88517cadaa395b

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Akademický článek

In vivo Two-Photon Imaging Reveals Acute Cerebral Vascular Spasm and Microthrombosis After Mild Traumatic Brain Injury in Mice

Autor: Xinjia Han, Zhi Chai, Xingjie Ping, Li-Juan Song, Cungen Ma, Yiwen Ruan, Xiaoming Jin

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Mild traumatic brain injury (mTBI), or concussion, is reported to interfere with cerebral blood flow and microcirculation in patients, but our current understanding is quite limited and the results are often controversial. Here we used longitudinal i

Externí odkaz: https://doaj.org/article/d1ad3870ac62452a8310ca9cc8fe6f9c

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Fasudil alleviates cerebral ischemia‑reperfusion injury by inhibiting inflammation and improving neurotrophic factor expression in rats

Autor: Min‑Fang Guo, Hui‑Yu Zhang, Pei‑Jun Zhang, Yi‑Jin Zhao, Jing‑Wen Yu, Tao Meng, Meng‑Di Li, Na Li, Cun‑Gen Ma, Li‑Juan Song, Jie‑Zhong Yu

Publikováno v: Acta Neurobiologiae Experimentalis.

The Rho kinase inhibitor fasudil exerts neuroprotective effects. We previously showed that fasudil can regulate M1/M2 microglia polarization and inhibit neuroinflammation. Here, the therapeutic effect of fasudil on cerebral ischemia‑reperfusion (I/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6231aedcaf61d148fa917ec7097d0c3
https://doi.org/10.55782/ane-2023-010

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Mdivi-1 Modulates Macrophage/Microglial Polarization in Mice with EAE via the Inhibition of the TLR2/4-GSK3β-NF-κB Inflammatory Signaling Axis

Autor: Xiaojuan Zhang, Yanhua Li, Jie-Zhong Yu, Xiuhua Xue, Xiaojie Niu, Peijun Zhang, Guo-Bin Song, Li-Juan Song, Qing Wang, Xiaoqin Liu, Cun-Gen Ma, Guoping Xi

Publikováno v: Molecular Neurobiology. 59:1-16

Macrophage/microglial modulation plays a critical role in the pathogenesis of multiple sclerosis (MS), which is an inflammatory disorder of the central nervous system. Dynamin-related protein 1 is a cytoplasmic molecule that regulates mitochondrial f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b4e6d1bc877432e0278b2324aa5edd9
https://doi.org/10.1007/s12035-021-02552-1

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[Acupuncture ameliorates neurological function by suppressing microglia polarization and inflammatory response after cerebral ischemia in rats]

Autor: Hui-Yu, Zhang, Yi-Jin, Zhao, Pei-Jun, Zhang, Min-Fang, Guo, Jing-Wen, Yu, Zhi, Chai, Cun-Gen, Ma, Li-Juan, Song, Jie-Zhong, Yu

Publikováno v: Zhen ci yan jiu = Acupuncture research. 47(11)

To observe the effect of acupuncture on microglia polarization and inflammatory reaction in rats with cerebral ischemia-reperfusion injury (CIRI), so as to explore its mechanisms underlying improvement of CIRI.Thirty male SD rats were randomly divide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3661fb552a6af02546755fd5905f1388
https://pubmed.ncbi.nlm.nih.gov/36453669

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