Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Li How Chen"'
Autor:
Götz Laible, Sally Cole, Brigid Brophy, Paul Maclean, Li How Chen, Dan P. Pollock, Lisa Cavacini, Nathalie Fournier, Christophe De Romeuf, Nicholas C. Masiello, William G. Gavin, David N. Wells, Harry M. Meade
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 11, Pp 638-652 (2020)
Abstract Therapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their availability. Goats, st
Externí odkaz:
https://doaj.org/article/d73ae4368bb047fabb8445784c9559a7
Autor:
Lisa A. Cavacini, Nathalie Fournier, Götz Laible, Paul S. MacLean, Harry M. Meade, Li How Chen, Dan Pollock, Brigid Brophy, Nicholas C. Masiello, Sally Cole, David N. Wells, Christophe De Romeuf, William G. Gavin
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 11, Pp 638-652 (2020)
FASEB BioAdvances
FASEB BioAdvances
Therapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their availability. Goats, striking a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0d8942d23d52cfec2c1f1cd9f9055b
https://doi.org/10.1101/2020.06.05.137463
https://doi.org/10.1101/2020.06.05.137463
Autor:
D Bonzo, Li How Chen, N. Buzzell, Daniel Pollock, William G. Gavin, N Hawkins, K. Miner, Harry M. Meade, Catherine A. Porter, S Blash
Publikováno v:
Transgenic research. 29(4)
At LFB USA, Inc., the ultimate use for transgenic cloned goats is for the production of recombinant human protein therapeutics in their milk. This retrospective analysis of the Somatic Cell Nuclear Transfer (SCNT) program, spanning from 1998 to 2010,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25e89825beeba5905a02441cb048dc9
https://pubmed.ncbi.nlm.nih.gov/32613547
https://pubmed.ncbi.nlm.nih.gov/32613547
Autor:
Margaret M. Destrempes, Harry M. Meade, Nicholas J. Mantis, Li-How Chen, Danielle E. Baranova
Publikováno v:
Pathogens and Immunity. 5:89
Background: In cholera epidemics, the spread of disease can easily outpace vaccine control measures. The advent of technologies enabling the expression of recombinant proteins, including antibodies, in the milk of transgenic animals raises the prospe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a77fff4115af58890e314941b08872
https://doi.org/10.20411/pai.v5i1.370
https://doi.org/10.20411/pai.v5i1.370
Autor:
Catherine A. Porter, N. Buzzell, William G. Gavin, Daniel Pollock, N Hawkins, Li How Chen, J. Pollock, Harry M. Meade, Yann Echelard, K. Miner, M. Schofield, J Howe, S Blash
Publikováno v:
Transgenic research. 27(1)
Production of transgenic founder goats involves introducing and stably integrating an engineered piece of DNA into the genome of the animal. At LFB USA, the ultimate use of these transgenic goats is for the production of recombinant human protein the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0d141358eecd844a961b52f070857f
https://pubmed.ncbi.nlm.nih.gov/29249046
https://pubmed.ncbi.nlm.nih.gov/29249046
Autor:
Margaret M. Destrempes, Carol Ziomek, Harry M. Meade, Evelyn Hayden, William G. Gavin, Robin E. Butler, Tanya Lewis, Li-How Chen, Yann Echelard, Nathan Hawkins, David Melican, Jennifer L. Williams, Esmail Behboodi
Publikováno v:
Theriogenology. 63:1549-1563
This work was performed within a commercial nuclear transfer program to investigate different methods for synchronizing donor cell cycle stage, for harvesting donor cells, and for fusion and activation of reconstructed caprine embryos. Primary fetal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb25968c7d51d1479e4f6556a71e75b
https://doi.org/10.1016/j.theriogenology.2004.05.029
https://doi.org/10.1016/j.theriogenology.2004.05.029
Autor:
Nick Masiello, Michael J. Schofield, William G. Gavin, Yann Echelard, Harry M. Meade, Li-How Chen
The clinical use of recombinant therapeutic proteins has increased significantly during the last few decades. However, therapeutic indications often require large amounts of highly purified product, especially for therapies that call for chronic dosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d7dcb98fdc19acdafd6f871b5e6a20
https://doi.org/10.1016/b978-0-12-386541-0.00026-6
https://doi.org/10.1016/b978-0-12-386541-0.00026-6
Autor:
Louis H. Miller, Harry M. Meade, Anthony W. Stowers, Lanling Zou, Lynn Lambert, Michael C. Kennedy, Allan Saul, Li-How Chen, David C. Kaslow, Carole A. Long, Yanling Zhang, Timothy J. Rice
Publikováno v:
Proceedings of the National Academy of Sciences. 99:339-344
Two strains of transgenic mice have been generated that secrete into their milk a malaria vaccine candidate, the 42-kDa C-terminal portion of Plasmodium falciparum merozoite surface protein 1 (MSP1 42 ). One strain secretes an MSP1 42 with an amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791df6921d043cbe2f4535b4832411a3
https://doi.org/10.1073/pnas.012590199
https://doi.org/10.1073/pnas.012590199
Autor:
Yann Echelard, H. Liem, D. Pollok, Jennifer L. Williams, Brian Wilburn, Li-How Chen, M. Harrington, Harry M. Meade
Publikováno v:
New Developments and New Applications in Animal Cell Technology ISBN: 0792350162
Mammary epithelial cell processing may be more efficient than that found in traditional cell cultures. Certain fusion proteins were not efficiently secreted from traditional cell culture, which includes COS and BHK cells. Yields of the proteins were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b55f4cb028675bcb99ae19062380d1
https://doi.org/10.1007/0-306-46860-3_138
https://doi.org/10.1007/0-306-46860-3_138