Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Li Chuan Chan"'
Autor:
Heng-Huan Lee, Ying-Nai Wang, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Yu-Han Wang, Zhou Jiang, Shouping Xu, Jun Yao, Yufan Qiu, Yi-Hsin Hsu, Wei-Lun Hwang, Meisi Yan, Jong-Ho Cha, Jennifer L. Hsu, Jia Shen, Yuanqing Ye, Xifeng Wu, Ming-Feng Hou, Lin-Ming Tseng, Shao-Chun Wang, Mei-Ren Pan, Chin-Hua Yang, Yuan-Liang Wang, Hirohito Yamaguchi, Da Pang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tum
Externí odkaz:
https://doaj.org/article/951d591c8f644e74b61e110feda5e096
Autor:
Mien-Chie Hung, Junjie Chen, Michael Curran, Nils-Petter Rudqvist, Chao-Hsien Chen, Ronald DePinho, Steven Lin, Akash Boda, Priyamvada Jayaprakash, Brittany Morrow, Rishika Prasad, Anupallavi Srinivasamani, Michelle Winkler, Rodney Cheng-En Hsieh, Sunil Krishnan, Ren-Chin Wu, Arthur Liu, Wen-Hao Hsu, Li-Chuan Chan, Krithikaa Bhanu, Ricardo De Azevedo, Yung-Chih Chou, Matthew Gubin, Eduardo Vilar-Sanchez, Ravaen Slay, Shweta Hegde, Genevieve Hartley, Spencer Lea, Coline Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Venkatesulu, Cullen Taniguchi, Betty Kim
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/167e52a6ae4147daa00f2698bdabe76d
Autor:
Lei Nie, Yongkun Wei, Fei Zhang, Yi-Hsin Hsu, Li-Chuan Chan, Weiya Xia, Baozhen Ke, Cihui Zhu, Rong Deng, Jun Tang, Jun Yao, Yu-Yi Chu, Xixi Zhao, Ye Han, Junwei Hou, Longfei Huo, How-Wen Ko, Wan-Chi Lin, Hirohito Yamaguchi, Jung-Mao Hsu, Yi Yang, Dean N. Pan, Jennifer L. Hsu, Celina G. Kleer, Nancy E. Davidson, Gabriel N. Hortobagyi, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.
Externí odkaz:
https://doaj.org/article/db070b7abc844972aa2cc8c48facb949
Autor:
Jung-Mao Hsu, Weiya Xia, Yi-Hsin Hsu, Li-Chuan Chan, Wen-Hsuan Yu, Jong-Ho Cha, Chun-Te Chen, Hsin-Wei Liao, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Shih-Shin Chang, Yi-Chun Chen, Guo-xin Ren, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising
Externí odkaz:
https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d85
Autor:
Yu-Yi Chu, Mei-Kuang Chen, Yongkun Wei, Heng-Huan Lee, Weiya Xia, Ying-Nai Wang, Clinton Yam, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Hirohito Yamaguchi, Zhou Jiang, Chunxiao Liu, Ching-Fei Li, Lei Nie, Li-Chuan Chan, Yuan Gao, Shao-Chun Wang, Jinsong Liu, Shannon N. Westin, Sanghoon Lee, Anil K. Sood, Liuqing Yang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Publikováno v:
Nature Cancer. 3:1211-1227
Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a substantial clinical challenge. In the present study, we report that anaplastic lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d293a3b218afe0677f1ed2685027c2
https://doi.org/10.1038/s43018-022-00438-2
https://doi.org/10.1038/s43018-022-00438-2
Autor:
Mien-Chie Hung, Dihua Yu, Haoqiang Ying, Shuqun Zhang, Jingkun Qu, Li-Chuan Chan, Riyao Yang, Wei-Chao Chang, Jennifer L. Hsu, Chunxiao Liu, Zhou Jiang, Jung-Mao Hsu, Yintao Li, Yu-Yi Chu, Yongkun Wei, Xixi Zhao
Targeting immune checkpoints such as programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has transformed cancer treatment, with durable clinical responses across a wide range of tumor types. However, a high percentage of patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecd668b5ac54ec7cede757aa3499aee
https://doi.org/10.1158/0008-5472.c.6513784
https://doi.org/10.1158/0008-5472.c.6513784
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Dihua Yu, Gordon B. Mills, Anil Sood, Aysegul A. Sahin, Mei-Kuang Chen, Jia Shen, Chia-Wei Li, Ming-Yang Wang, Yuan-Ching Chang, Chien-Liang Liu, Wen-Chien Huang, Yun Wu, Yongkun Wei, Yueh-Fu Fang, Jennifer L. Hsu, Ting-Jung Wu, Li-Chuan Chan, Jun Yao, Yi-Hsin Hsu
Supplementary Figure S1. The mRNA expression of MAP4K5, TRIO, EPHA4, DGKA and MAPK7 in TNBC cells Supplementary Figure S2. Inhibition of PKC-alpha, MET, and CDK6 reduced stem cell-like population.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721b4404f5679320e733d37775ac2613
https://doi.org/10.1158/0008-5472.22403955.v1
https://doi.org/10.1158/0008-5472.22403955.v1
Autor:
Xian Sun, Wei-Jan Wang, Jilu Lang, Riyao Yang, Wan-Jou Shen, Linlin Sun, Jung-Mao Hsu, Li-Chuan Chan, Chia-Wei Li, Weiya Xia, Baozhen Ke, Guodong Yao, Kebin Huang, Pei-Chih Lee, Koller, Paul B., Mien-Chie Hung
Publikováno v:
International Journal of Biological Sciences; 2023, Vol. 19 Issue 14, p4644-4656, 13p
Autor:
Chia-Wei Li, Seung-Oe Lim, Weiya Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, Kay-Hooi Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Qingqing Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, Aysegul A. Sahin, James P. Allison, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-me
Externí odkaz:
https://doaj.org/article/95bbbbb825d74f9a9d75ce9718db0cfa
Autor:
Lei Nie, Yongkun Wei, Fei Zhang, Yi-Hsin Hsu, Li-Chuan Chan, Weiya Xia, Baozhen Ke, Cihui Zhu, Rong Deng, Jun Tang, Jun Yao, Yu-Yi Chu, Xixi Zhao, Ye Han, Junwei Hou, Longfei Huo, How-Wen Ko, Wan-Chi Lin, Hirohito Yamaguchi, Jung-Mao Hsu, Yi Yang, Dean N. Pan, Jennifer L. Hsu, Celina G. Kleer, Nancy E. Davidson, Gabriel N. Hortobagyi, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/532c0da0df584f4bbb5da078024d15e6