Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Li−Hsuan Yen"'
Autor:
Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Glycolytic enzymes are challenging drug targets due to their highly conserved active sites and phosphorylated substrates. Here, the authors identify fast acting allosteric inhibitors of Trypanosoma brucei phosphofructokinase that block trypanosome gl
Externí odkaz:
https://doaj.org/article/4b5f2d939f554cc8b893fd1148232b4e
Publikováno v:
Journal of Colloid and Interface Science. 625:354-362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53a4e98f8fdd9a780b9773e1c612a0e
https://doi.org/10.1016/j.jcis.2022.06.033
https://doi.org/10.1016/j.jcis.2022.06.033
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121424 (2015)
A major challenge in the field of ligand discovery is to identify chemically useful fragments that can be developed into inhibitors of specific protein-protein interactions. Low molecular weight fragments (with molecular weight less than 250 Da) are
Externí odkaz:
https://doaj.org/article/400af3d3c9bc40dbb710989c2b88c3e8
Autor:
James Kinkead, Ryan Ritchie, Paul A.M. Michels, Simon N. Pettit, Adrian J. Highton, Jeremy C. Mottram, Elizabeth A. Blackburn, Carol Austin, Martin Walker, Martin A. Wear, Antonio K. Vong, Malcolm D. Walkinshaw, Andrew John Keats, Scott P. Webster, Divya Malik, Nick Gray, Chris Swain, Li-Hsuan Yen, Iain W. McNae, Peter M Fernandes, Jacqueline Dornan, Elmarie Myburgh
Publikováno v:
McNae, I W, Kinkead, J, Malik, D, Yen, L-H, Walker, M K, Swain, C, Webster, S P, Gray, N, Fernandes, P M, Myburgh, E, Blackburn, E A, Ritchie, R, Austin, C, Wear, M A, Highton, A J, Keats, A J, Vong, A, Dornan, J, Mottram, J C, Michels, P A M, Pettit, S & Walkinshaw, M D 2021, ' Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice ', Nature Communications, vol. 12, no. 1, 1052 . https://doi.org/10.1038/s41467-021-21273-6
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799da05836121fe3900af19fdb8614ee
https://hdl.handle.net/20.500.11820/ba80df50-0eee-4cf5-92f8-bfbfbb7b3473
https://hdl.handle.net/20.500.11820/ba80df50-0eee-4cf5-92f8-bfbfbb7b3473
Autor:
Li-Hsuan Yen, 顏立軒
107
The main purpose of this thesis is to research whether there is a negative correlation between the Taiwan identity and the willingness to work in China for students from National Taiwan University. In addition, this study incorporates studen
The main purpose of this thesis is to research whether there is a negative correlation between the Taiwan identity and the willingness to work in China for students from National Taiwan University. In addition, this study incorporates studen
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/gra38m
Effect of ligands and redox state on phosphofructokinase quaternary structure and enzymatic activity
Autor:
Peter M Fernandes, Li-Hsuan Yen, Iain W. McNae, James Kinkead, Malcolm D. Walkinshaw, Paul A.M. Michels
Publikováno v:
The Lancet. 389:S36
Background Alterations in glycolytic flux are characteristic of cancer cells and have recently been linked to Alzheimer's disease. Phosphofructokinase (PFK) activity is a key regulator of glycolysis and also modulates apoptosis. PFK has a complex qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ec6116bb6530e46f7638fb7f3dbd7d
https://doi.org/10.1016/s0140-6736(17)30432-4
https://doi.org/10.1016/s0140-6736(17)30432-4
Publikováno v:
FUZZ-IEEE
Involvement has become an important variable in consumer behavior and marketing research for a long time. The purpose of this study is to develop a model that can explain the complicated relationship between antecedents, consequences, and different t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3d8b6f7eaf835e2c386593ca9a0e1b
https://doi.org/10.1109/fuzzy.2008.4630461
https://doi.org/10.1109/fuzzy.2008.4630461
Publikováno v:
2008 IEEE International Conference on Fuzzy Systems (IEEE World Congress on Computational Intelligence); 2008, p790-796, 7p