Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Li‐Huei Tsai"'
Autor:
Daniela Rodrigues-Amorim, P. Lorenzo Bozzelli, TaeHyun Kim, Liwang Liu, Oliver Gibson, Cheng-Yi Yang, Mitchell H. Murdock, Fabiola Galiana-Melendez, Brooke Schatz, Alexis Davison, Md Rezaul Islam, Dong Shin Park, Ravikiran M. Raju, Fatema Abdurrob, Alissa J. Nelson, Jian Min Ren, Vicky Yang, Matthew P. Stokes, Li-Huei Tsai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability of axons to
Externí odkaz:
https://doaj.org/article/8ebed6b59c0b464ab74100e9c4457c3e
Autor:
Chinnakkaruppan Adaikkan, Justin Joseph, Georgios Foustoukos, Jun Wang, Denis Polygalov, Roman Boehringer, Steven J. Middleton, Arthur J. Y. Huang, Li-Huei Tsai, Thomas J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The precise temporal coordination of neural activity is crucial for brain function. In the hippocampus, this precision is reflected in the oscillatory rhythms observed in CA1. While it is known that a balance between excitatory and inhibitor
Externí odkaz:
https://doaj.org/article/2da85b1e3b9e4d61898c937713e93409
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The risk for neurodegenerative diseases increases with aging, with various pathological conditions and functional deficits accompanying these diseases. We have previously demonstrated that non-invasive visual stimulation using 40 Hz light flicker ame
Externí odkaz:
https://doaj.org/article/ffb1e80699e5468aa759857b880f3efd
Autor:
Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymo
Externí odkaz:
https://doaj.org/article/ceb332e45eeb48778b5b9d9ca1cfaaef
Autor:
Ping-Chieh Pao, Li-Huei Tsai
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-17 (2021)
Abstract Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of
Externí odkaz:
https://doaj.org/article/dfd4c72762814078a5665ef7d1a37a87
Autor:
Deborah O. Dele-Oni, Karen E. Christianson, Shawn B. Egri, Alvaro Sebastian Vaca Jacome, Katherine C. DeRuff, James Mullahoo, Vagisha Sharma, Desiree Davison, Tak Ko, Michael Bula, Joel Blanchard, Jennie Z. Young, Lev Litichevskiy, Xiaodong Lu, Daniel Lam, Jacob K. Asiedu, Caidin Toder, Adam Officer, Ryan Peckner, Michael J. MacCoss, Li-Huei Tsai, Steven A. Carr, Malvina Papanastasiou, Jacob D. Jaffe
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-10 (2021)
Measurement(s) drug perturbation response Technology Type(s) proteomic profiling Factor Type(s) cell line • drug Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9
Externí odkaz:
https://doaj.org/article/b86900b2f9b8425aac6d9c1d14f49b98
Autor:
Murat Yildirim, Chloe Delepine, Danielle Feldman, Vincent A Pham, Stephanie Chou, Jacque Ip, Alexi Nott, Li-Huei Tsai, Guo-Li Ming, Peter TC So, Mriganka Sur
Publikováno v:
eLife, Vol 11 (2022)
Human cerebral organoids are unique in their development of progenitor-rich zones akin to ventricular zones from which neuronal progenitors differentiate and migrate radially. Analyses of cerebral organoids thus far have been performed in sectioned t
Externí odkaz:
https://doaj.org/article/97960da12b624a7a9c5693f4d8bbdf34
Autor:
Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-27 (2020)
Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK
Externí odkaz:
https://doaj.org/article/7b9677d83e734c9bb4414abb7d975e62
Autor:
Ping-Chieh Pao, Debasis Patnaik, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X. Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J. Haggarty, Li-Huei Tsai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseas
Externí odkaz:
https://doaj.org/article/31affdab15104a389accac5fde35981f
Autor:
Diane Chan, Ho-Jun Suk, Brennan L Jackson, Noah P Milman, Danielle Stark, Elizabeth B Klerman, Erin Kitchener, Vanesa S Fernandez Avalos, Gabrielle de Weck, Arit Banerjee, Sara D Beach, Joel Blanchard, Colton Stearns, Aaron D Boes, Brandt Uitermarkt, Phillip Gander, Matthew Howard, Eliezer J Sternberg, Alfonso Nieto-Castanon, Sheeba Anteraper, Susan Whitfield-Gabrieli, Emery N Brown, Edward S Boyden, Bradford C Dickerson, Li-Huei Tsai
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278412 (2022)
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, and improves behavioral testing performance in mouse models of AD. Here, we
Externí odkaz:
https://doaj.org/article/9e5f19da294640a8930e1b77d5f60672