Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Li‐Feng Xu"'
Autor:
Li-peng Yao, Zheng-kai Wang, Xin-qing Jiang, Beier Jiang, Si-jia Chen, Zhi-dan Hua, Dan-dan Gao, Quan Zheng, Sheng-mei Zhu, Mao-xiang Qian, Feng Zhang, Li-feng Xu, Cheng-shui Chen, Fang Lu
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Chronic obstructive pulmonary disease (COPD) is an irreversible and progressive chronic inflammatory lung disease which affects millions of people worldwide. Activated fibroblasts are observed to accumulate in lung of COPD patients and promo
Externí odkaz:
https://doaj.org/article/be29dd451f88458daee65b4de140beeb
Autor:
Fang Lu, Li-peng Yao, Dan-dan Gao, Tahereh Alinejad, Xin-qing Jiang, Qi Wu, Qiao-cheng Zhai, Ming Liu, Sheng-mei Zhu, Mao-xiang Qian, Li-feng Xu, Cheng-shui Chen, Feng Zhang
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Chronic obstructive pulmonary disease (COPD) is a leading aging related cause of global mortality. Small airway narrowing is recognized as an early and significant factor for COPD development. Senescent fibroblasts were observed to accumulat
Externí odkaz:
https://doaj.org/article/e1de5be26365496cb3134d0ca6f2fa03
Autor:
Hang-fei Chen, Zhang-ping Li, Qi Wu, Chun Yu, Jing-Yi Yan, Yong-feng Bai, Sheng-mei Zhu, Mao-xiang Qian, Ming Liu, Li-feng Xu, Zheng Peng, Feng Zhang
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23167- (2024)
Hyperactivation of ribosome biosynthesis (RiBi) is a hallmark of cancer, and targeting ribosome biogenesis has emerged as a potential therapeutic strategy. The depletion of TAF1B, a major component of selectivity factor 1 (SL1), disrupts the pre-init
Externí odkaz:
https://doaj.org/article/f6a9d51cd35f4ccbbcdca3ba33e96da1
Autor:
Hang-fei Chen, Dan-dan Gao, Xin-qing Jiang, Hao Sheng, Qi Wu, Quan Zheng, Qiao-cheng Zhai, Lei Yuan, Ming Liu, Li-feng Xu, Mao-xiang Qian, Heng Xu, Jian Fang, Feng Zhang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundTAF1B (TATA Box Binding Protein (TBP)-Associated Factor) is an RNA polymerase regulating rDNA activity, stress response, and cell cycle. However, the function of TAF1B in the progression of hepatocellular carcinoma (HCC) is unknown.Objectiv
Externí odkaz:
https://doaj.org/article/6658ca29664c4e6d8978c816dab993fe
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background With the emergence of CRISPR/Cas9 technology, multiple gene editing procedures became available for the silkworm. Although binary transgene-based methods have been widely used to generate mutants, delivery of the CRISPR/Cas9 syste
Externí odkaz:
https://doaj.org/article/0478f5323894419d84b56370af38f845
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The incidence and mortality of gastric cancer ranks as a fouth leading cause of cancer death worldwide, especially in East Asia. Due to the lack of specific early-stage symptoms, the majority of patients in most developing nations are diagnosed at an
Externí odkaz:
https://doaj.org/article/775e5300ce164ca5b031b89b3073c27c
Autor:
Si-wei Wang, Tian Lan, Hang-fei Chen, Hao Sheng, Chun-yi Xu, Li-feng Xu, Fang Zheng, Feng Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
NAFLD is the most prevalent liver disease in human history. The treatment is still limited yet. In the current study, we reported that limonin inhibited hepatic lipid accumulation and fatty acid synthesis in HFD fed mice. Using AMPK inhibitor and AMP
Externí odkaz:
https://doaj.org/article/8a95095c2b4547f1a667af4bae1b0481
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 6, Pp o1923-o1923 (2012)
In the title compound, C25H13Cl2F4N3, there are four planar systems, viz. three benzene rings and a pyrazolo[1,5-a]pyrimidine system [r.m.s. deviation = 0.002 Å]. The dihedral angle between the dichlorophenyl ring and the unsubstituted phenyl ring i
Externí odkaz:
https://doaj.org/article/ceb924940c274e669aa2f21784581348
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 5, Pp o1515-o1515 (2012)
In the title compound, C20H11Cl2F4N3, the central pyrazolo[1,5-a]pyrimidine unit is almost planar [the mean deviation from the best least-square plane through the nine atoms is 0.006 (2) Å]. The fluorobenzene ring is rotated out of this plane by 10.
Externí odkaz:
https://doaj.org/article/b9d2cee59ba94f7381751f7ffd4387f5
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 4, Pp o1142-o1142 (2012)
In the title compound, C16H9Cl2N5O2, the folded molecular conformation is characterized by a dihedral angle between the two benzene rings of 74.03 (5)°. An intramolecular N—H...O hydrogen bond is observed between the H atom of the amide group and
Externí odkaz:
https://doaj.org/article/b48553ac8330424e801cb2748b648237