Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Li Kim Lee"'
Publikováno v:
Nucleic Acids Research
The widespread utilization of gene silencing techniques, such as antisense, is impeded by the poor cellular delivery of oligonucleotides (ONs). Rational design of carriers for enhanced ON delivery demands a better understanding of the role of the vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e106ae1af87b270defa9777dcf948459
https://doi.org/10.1093/nar/gkm450
https://doi.org/10.1093/nar/gkm450
Publikováno v:
Annals of the New York Academy of Sciences. 1082:47-51
We aim to compare quantitatively the dynamics of the effectiveness of antisense oligonucleotides (AS ODNs) versus short interfering RNAs (siRNAs) and relate their effectiveness to sequence metrics (e.g., predicted free energy of binding). AS ODNs aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540c17d7b1cd73d27641a2c6ef00444a
https://doi.org/10.1196/annals.1348.061
https://doi.org/10.1196/annals.1348.061
Autor:
Li Kim Lee, Charles M. Roth
Publikováno v:
Current Opinion in Biotechnology. 14:505-511
Antisense technology is finding increasing application not only in clinical development, but also for cellular engineering. Several types of antisense methods (e.g. antisense oligonucleotides, antisense RNA and small interfering RNA) can be used to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c05bce572e637aa345f157e7a33c4c
https://doi.org/10.1016/s0958-1669(03)00115-0
https://doi.org/10.1016/s0958-1669(03)00115-0
Publikováno v:
Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference.
The objective of this work is to investigate the role of the vector in the dynamics of antisense effects. Polymer/DNA complexs between cationic, branched polymer, polyethylenimine (PEI) at a range of molecular weights and oligonucleotides (ODNs), wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ae4ee5629f65e301f1d0d68cffcf12
https://doi.org/10.1109/nebc.2006.1629812
https://doi.org/10.1109/nebc.2006.1629812
Publikováno v:
Biomacromolecules. 7(5)
The use of antisense oligodeoxynucleotides (ODNs) to inhibit the expression of specific mRNA targets represents a powerful technology for control of gene expression. Cationic lipids and polymers are frequently used to improve the delivery of ODNs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ae668501144e8f1a117fedfcf15f80
https://pubmed.ncbi.nlm.nih.gov/16677032
https://pubmed.ncbi.nlm.nih.gov/16677032
Publikováno v:
Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005..
The use of antisense oligonucleotides (AS ODNs) to inhibit the expression of specific mRNA targets represents a powerful bioengineering strategy for inhibition of gene expression. Cationic lipids and polymers are frequently used to improve the delive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ffc9d0dac1fe2b748ab2e2ae12e80fd
https://doi.org/10.1109/nebc.2005.1431986
https://doi.org/10.1109/nebc.2005.1431986
Autor:
Supti Sarkar, Parviz Ayazi Shamlou, Stephen L. Hart, Helen C. Hailes, Li Kim Lee, Susana M. Levy, Alethea B. Tabor
Publikováno v:
Biotechnology and applied biochemistry. 41(Pt 2)
We used static light scattering to obtain new measurements on the internal structure of aggregated non-viral gene-delivery particles in colloidal suspension. The vector particles are prepared by charge neutralization of plasmid DNA either by poly-L-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036cfaf65bbfa335b508d32334701dc3
https://pubmed.ncbi.nlm.nih.gov/15242334
https://pubmed.ncbi.nlm.nih.gov/15242334
Autor:
Supti Sarkar, Li Kim Lee, Stephen L. Hart, Helen C. Hailes, Susana M. Levy, Alethea Tabor, Parviz Ayazi Shamlou
Publikováno v:
Biotechnology & Applied Biochemistry; 2005, Vol. 041 Issue 2, p127-136, 10p
Publikováno v:
Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference; 2006, p181-182, 2p