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The reliability of a high-throughput biological experiment relies highly on the settings of the operational factors in its experimental and data-analytic procedures. Understanding how operational factors influence the reproducibility of the experimen
Externí odkaz:
http://arxiv.org/abs/1807.00943
Autor:
Zhang, Feipeng, Li, Qunhua
Expectile regression is a useful tool for exploring the relation between the response and the explanatory variables beyond the conditional mean. This article develops a continuous threshold expectile regression for modeling data in which the effect o
Externí odkaz:
http://arxiv.org/abs/1611.02609
Autor:
Zhang, Feipeng, Li, Qunhua
We introduce a rank-based bent linear regression with an unknown change point. Using a linear reparameterization technique, we propose a rank-based estimate that can make simultaneous inference on all model parameters, including the location of the c
Externí odkaz:
http://arxiv.org/abs/1606.02234
Autor:
Seal, Souvik1 (AUTHOR) souvik.seal@cuanschutz.edu, Li, Qunhua2 (AUTHOR), Basner, Elle Butler2 (AUTHOR), Saba, Laura M.3 (AUTHOR), Kechris, Katerina1 (AUTHOR)
Publikováno v:
PLoS Computational Biology. 1/6/2023, Vol. 19 Issue 1, p1-26. 26p. 2 Diagrams, 5 Charts, 7 Graphs.
Publikováno v:
Journal of the American Statistical Association, 2018 Sep 01. 113(523), 1028-1039.
Externí odkaz:
https://www.jstor.org/stable/45029728
Autor:
Li, Qunhua, Zhang, Feipeng
Publikováno v:
Biometrics, 2018 Sep 01. 74(3), 803-813.
Externí odkaz:
https://www.jstor.org/stable/45092936
Publikováno v:
Annals of Applied Statistics 2012, Vol. 6, No. 4, 1775-1794
Mass spectrometry provides a high-throughput approach to identify proteins in biological samples. A key step in the analysis of mass spectrometry data is to identify the peptide sequence that, most probably, gave rise to each observed spectrum. This
Externí odkaz:
http://arxiv.org/abs/1301.2467
Publikováno v:
Annals of Applied Statistics 2011, Vol. 5, No. 3, 1752-1779
Reproducibility is essential to reliable scientific discovery in high-throughput experiments. In this work we propose a unified approach to measure the reproducibility of findings identified from replicate experiments and identify putative discoverie
Externí odkaz:
http://arxiv.org/abs/1110.4705
Publikováno v:
Annals of Applied Statistics 2010, Vol. 4, No. 2, 962-987
Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides. The resulting mixture of peptides is then subjected to mass s
Externí odkaz:
http://arxiv.org/abs/1011.2087