Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Lhassane, Ismaili"'
Autor:
Ghada Ben Ameur, Emna Maalej, Helene Martin, Anne-Sophie Jacquinot, Nadine Barbanneau, Paul J. Bernard, José Marco-Contelles, Fakher Chabchoub, Lhassane Ismaili
Publikováno v:
Chemistry, Vol 6, Iss 4, Pp 695-705 (2024)
Eleven new differently substituted N,7-diphenylpyrimido [4,5-d]pyrimidin-4-amines 4a–k were synthesized from readily available reagents in a simple and inexpensive two-step procedure with yields up to 57%. Neuroprotective analysis against H2O2 and
Externí odkaz:
https://doaj.org/article/9019af1564a9476d973ff43077d4706c
Autor:
Sébastien Pasquereau, Mathilde Galais, Maxime Bellefroid, Irene Pachón Angona, Stéphanie Morot-Bizot, Lhassane Ismaili, Carine Van Lint, Georges Herbein
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract A novel coronavirus, SARS-CoV-2, emerged in China at the end of 2019 causing a large global outbreak. As treatments are of the utmost importance, drugs with broad anti-coronavirus activity embody a rich and rapid drug discovery landscape, wh
Externí odkaz:
https://doaj.org/article/9f38cbc361794829bdc7ad0b2417c674
Autor:
Irene Pachón-Angona, Paul J. Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María-Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 121 (2024)
This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds 4a–l, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxida
Externí odkaz:
https://doaj.org/article/91b84aaa929141c3b798a1c55836bddf
Autor:
Lhassane Ismaili
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/5ae267d4eaed419abde7300d01b611bc
Autor:
Emelina R. Rodríguez-Ruiz, Raquel Herrero-Labrador, Ana P. Fernández-Fernández, Julia Serrano-Masa, José A. Martínez-Montero, Daniel González-Nieto, Mayuri Hana-Vaish, Mohamed Benchekroun, Lhassane Ismaili, José Marco-Contelles, Ricardo Martínez-Murillo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12254 (2023)
Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer’s disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine–fe
Externí odkaz:
https://doaj.org/article/dbe06503d32d4410b60bea940048ddc2
Autor:
Imen Dakhlaoui, Paul J. Bernard, Diana Pietrzak, Alexey Simakov, Maciej Maj, Bernard Refouvelet, Arnaud Béduneau, Raphaël Cornu, Krzysztof Jozwiak, Fakher Chabchoub, Isabel Iriepa, Helene Martin, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9742 (2023)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that has a heavy social and economic impact on all societies and for which there is still no cure. Multitarget-directed ligands (MTDLs) seem to be a promising therapeutic strate
Externí odkaz:
https://doaj.org/article/97c53b9220af4096b1a547bc5b7e590c
Autor:
Carina Lemke, Joscha Christmann, Jiafei Yin, José M. Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Ismaili, María Angeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Florian M. Dato, Ulrike Bartz, Paul W. Elsinghorst, Markus Pietsch, Christa E. Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow
Publikováno v:
ACS Omega, Vol 4, Iss 26, Pp 22161-22168 (2019)
Externí odkaz:
https://doaj.org/article/266dc0bdc6b74364bac17b0fdeeb44a1
Autor:
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Publikováno v:
Molecules, Vol 28, Iss 1, p 71 (2022)
Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel
Externí odkaz:
https://doaj.org/article/c1008cfa0311472f9605360beca986c5
Autor:
Emna Choura, Fares Elghali, Paul J. Bernard, Dhouha Msalbi, José Marco-Contelles, Sami Aifa, Lhassane Ismaili, Fakher Chabchoub
Publikováno v:
Molecules, Vol 27, Iss 22, p 7878 (2022)
Ten new differently substituted 3-benzyl-5-aryl-3,5-dihydro-4H-benzo[6,7]chromeno[2,3-d]pyrimidin-4,6,11-triones 3 were synthesized by a simple and cost-efficient procedure in a one-pot, three-component reaction from readily available ethyl 2-amino-4
Externí odkaz:
https://doaj.org/article/680d832206084032814164729d9f5c95
Autor:
Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small
Externí odkaz:
https://doaj.org/article/0bac54c2f9864ac794fb57250198766b