Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lezheng Yu"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4836-4848 (2023)
Autophagy is a primary mechanism for maintaining cellular homeostasis. The synergistic actions of autophagy-related (ATG) proteins strictly regulate the whole autophagic process. Therefore, accurate identification of ATGs is a first and critical step
Externí odkaz:
https://doaj.org/article/95268131af7c42ccabd835f5ac0d46e0
Publikováno v:
Journal of Advanced Research, Vol 41, Iss , Pp 219-231 (2022)
Introduction: The top priority in drug development is to identify novel and effective drug targets. In vitro assays are frequently used for this purpose; however, traditional experimental approaches are insufficient for large-scale exploration of nov
Externí odkaz:
https://doaj.org/article/87ae38c375714e028f6a8032983cd030
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Post-transcriptionally RNA modifications, also known as the epitranscriptome, play crucial roles in the regulation of gene expression during development. Recently, deep learning (DL) has been employed for RNA modification site prediction and has show
Externí odkaz:
https://doaj.org/article/f4259417139148eab9743d2d66870551
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105530- (2022)
Summary: Despite the impressive success of deep learning techniques in various types of classification and prediction tasks, interpreting these models and explaining their predictions are still major challenges. In this article, we present an easy-to
Externí odkaz:
https://doaj.org/article/6c0f63a6631d42fd87f22169ea443cc9
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 862-870 (2020)
Cancer is one of the most dangerous diseases to human health. The accurate prediction of anticancer peptides (ACPs) would be valuable for the development and design of novel anticancer agents. Current deep neural network models have obtained state-of
Externí odkaz:
https://doaj.org/article/838017e6dade4e359863bb7c5c1e85e1
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
DNA N4-methylcytosine (4mC) is a pivotal epigenetic modification that plays an essential role in DNA replication, repair, expression and differentiation. To gain insight into the biological functions of 4mC, it is critical to identify their modificat
Externí odkaz:
https://doaj.org/article/f31c3e4875854f409a317f65df60a998
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Gram-negative bacteria can deliver secreted proteins (also known as secreted effectors) directly into host cells through type III secretion system (T3SS), type IV secretion system (T4SS), and type VI secretion system (T6SS) and cause various diseases
Externí odkaz:
https://doaj.org/article/50b7b73d4b7b45408e4c89d82e391fbe
Publikováno v:
ACS Omega.
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 862-870 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Cancer is one of the most dangerous diseases to human health. The accurate prediction of anticancer peptides (ACPs) would be valuable for the development and design of novel anticancer agents. Current deep neural network models have obtained state-of
Publikováno v:
NAR Genomics and Bioinformatics
Type III secretion systems (T3SSs) are bacterial membrane-embedded nanomachines that allow a number of humans, plant and animal pathogens to inject virulence factors directly into the cytoplasm of eukaryotic cells. Export of effectors through T3SSs i