Multi-ancestral origin of intestinal tumors: Impact on growth, progression, and drug efficacy.

Autor: Leystra AA; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Division of Gastroenterology and Hepatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Gilsdorf BJ; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Wisinger AM; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Warda ER; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Wiegand S; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Zahm CD; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Matkowskyj KA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Deming DA; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Khan N; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA., Rosemarie Q; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Sievers CK; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Division of Gastroenterology and Hepatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Schwartz AR; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Albrecht DM; Division of Gastroenterology and Hepatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Clipson L; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Mukhtar H; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA., Newton MA; Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Halberg RB; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; Division of Gastroenterology and Hepatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

Publikováno v: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2022 Feb; Vol. 5 (2), pp. e1459. Date of Electronic Publication: 2021 Jul 10.

Novel Protein-Based Vaccine against Self-Antigen Reduces the Formation of Sporadic Colon Adenomas in Mice.

Autor: Belnoue E; AMAL Therapeutics, Fondation pour Recherches Médicales, 64 avenue de la Roseraie, 1205 Geneva, Switzerland.; Boehringer Ingelheim International GmbH, 55216 Ingelheim, Germany., Leystra AA; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Carboni S; AMAL Therapeutics, Fondation pour Recherches Médicales, 64 avenue de la Roseraie, 1205 Geneva, Switzerland.; Boehringer Ingelheim International GmbH, 55216 Ingelheim, Germany., Cooper HS; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.; Department of Pathology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Macedo RT; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Harvey KN; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Colby KB; Blood Cell Development and Function Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Campbell KS; Blood Cell Development and Function Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Vanderveer LA; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Clapper ML; Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA., Derouazi M; AMAL Therapeutics, Fondation pour Recherches Médicales, 64 avenue de la Roseraie, 1205 Geneva, Switzerland.; Boehringer Ingelheim International GmbH, 55216 Ingelheim, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2021 Feb 17; Vol. 13 (4). Date of Electronic Publication: 2021 Feb 17.

Understanding Intratumoral Heterogeneity: Lessons from the Analysis of At-Risk Tissue and Premalignant Lesions in the Colon.

Autor: Sievers CK; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Leystra AA; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Clipson L; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin., Dove WF; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin., Halberg RB; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. University of Wisconsin Carbone Cancer Center, Madison, Wisconsin. rbhalberg@medicine.wisc.edu.

Publikováno v: Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2016 Aug; Vol. 9 (8), pp. 638-41. Date of Electronic Publication: 2016 May 19.

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.

Autor: Yueh AE; Division of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America., Payne SN; University of Wisconsin Carbone Cancer Center, Madison, WI, United States of America., Leystra AA; Department of Oncology, University of Wisconsin Madison, Madison, WI, United States of America., Van De Hey DR; Division of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America., Foley TM; Division of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America., Pasch CA; University of Wisconsin Carbone Cancer Center, Madison, WI, United States of America., Clipson L; Department of Oncology, University of Wisconsin Madison, Madison, WI, United States of America., Matkowskyj KA; University of Wisconsin Carbone Cancer Center, Madison, WI, United States of America.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America.; William S Middleton Memorial Veterans Hospital, Madison, WI, United States of America., Deming DA; Division of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America.; University of Wisconsin Carbone Cancer Center, Madison, WI, United States of America.; William S Middleton Memorial Veterans Hospital, Madison, WI, United States of America.

Publikováno v: PloS one [PLoS One] 2016 Feb 10; Vol. 11 (2), pp. e0148730. Date of Electronic Publication: 2016 Feb 10 (Print Publication: 2016).

Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.

Autor: Hadac JN; Department of Oncology, University of Wisconsin, Madison, Wisconsin., Leystra AA; Department of Oncology, University of Wisconsin, Madison, Wisconsin., Paul Olson TJ; Division of General Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin., Maher ME; Division of Hematology and Oncology, University of Wisconsin, Madison, Wisconsin., Payne SN; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin., Yueh AE; Division of Hematology and Oncology, University of Wisconsin, Madison, Wisconsin., Schwartz AR; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, Wisconsin., Albrecht DM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, Wisconsin., Clipson L; Department of Oncology, University of Wisconsin, Madison, Wisconsin., Pasch CA; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin., Matkowskyj KA; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin. William S Middleton Memorial Veterans Hospital, Madison, Wisconsin., Halberg RB; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin. Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, Wisconsin., Deming DA; Division of Hematology and Oncology, University of Wisconsin, Madison, Wisconsin. University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin. William S Middleton Memorial Veterans Hospital, Madison, Wisconsin. ddeming@medicine.wisc.edu.

Publikováno v: Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2015 Oct; Vol. 8 (10), pp. 952-61. Date of Electronic Publication: 2015 Aug 14.