Lipophilic nalmefene prodrugs to achieve a one-month sustained release

Autor: Gaekens, Tim, Guillaume, Michel, Borghys, Herman, De Zwart, Loeckie L., de Vries, Ronald, Embrechts, Roger C.A., Vermeulen, An, Megens, Anton A.H.P., Leysen, Josée E., Herdewijn, Piet, Annaert, Pieter P., Atack, John R.

Publikováno v: In Journal of Controlled Release 28 June 2016 232:196-202

Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors

Autor: Christiaans, Johannes A.M., Klein, Pieter J., Metaxas, Athanasios, Kooijman, Esther J.M., Schuit, Robert C., Leysen, Josée E., Lammertsma, Adriaan A., van Berckel, Bart N.M., Windhorst, Albert D.

Publikováno v: In Nuclear Medicine and Biology September 2014 41(8):670-680

Radiosynthesis and biodistribution of a histamine H 3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[ 11C]benzyl]-morpholine: evaluation of a potential PET ligand

Autor: Airaksinen, Anu J., Jablonowski, Jill A., van der Mey, Margreet, Barbier, Ann J., Klok, Rob P., Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D.M., Leysen, Josee E., Carruthers, Nicholas I., Lammertsma, Adriaan A., Windhorst, Albert D.

Publikováno v: In Nuclear Medicine and Biology 2006 33(6):801-810

Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist

Autor: Metaxas, Athanasios, van Berckel, Bart N. M., Klein, Pieter J., Verbeek, Joost, Nash, Emily C., Kooijman, Esther J. M., Renjaän, V. ronique A., Golla, Sandeep S. V., Boellaard, Ronald, Christiaans, Johannes A. M., Windhorst, Albert D., Leysen, Josée E.

Publikováno v: Metaxas, A, van Berckel, B N M, Klein, P J, Verbeek, J, Nash, E C, Kooijman, E J M, Renjaän, V R A, Golla, S S V, Boellaard, R, Christiaans, J A M, Windhorst, A D & Leysen, J E 2019, ' Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N′-(3-[ 3 H] 3 methoxy phenyl)-N′-methylguanidine ([ 3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ', Pharmacology Research and Perspectives, vol. 7, no. 1, e00458 . https://doi.org/10.1002/prp2.458
Pharmacology Research and Perspectives, 7(1):e00458. Wiley-Blackwell Publishing Ltd

Labeled with carbon-11, N-(2-chloro-5-thiomethylphenyl)-N′-(3-methoxyphenyl)-N′-methylguanidine ([ 11 C]GMOM) is currently the only positron emission tomography (PET) tracer that has shown selectivity for the ion-channel site of N-methyl-D-aspart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::35a6cdf4164c55c044af2ae74b57aaa0
https://research.vumc.nl/en/publications/212b257e-1fc7-49c6-a976-7b4f044ca42d

5-HT2A and 5-HT2C receptors and their atypical regulation properties

Autor: Van Oekelen, Dirk, Luyten, Walter H.M.L, Leysen, Josée E ^*

Publikováno v: In Life Sciences 18 April 2003 72(22):2429-2449