Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Leyre Silva"'
Autor:
Belén Aparicio, Marta Ruiz, Noelia Casares, Leyre Silva, Josune Egea, Patricia Pérez, Guillermo Albericio, Mariano Esteban, Juan García-Arriaza, Juan J. Lasarte, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3f530582438844589d1f5450ea62cfdf
Autor:
Belén Aparicio, Marta Ruiz, Noelia Casares, Leyre Silva, Josune Egea, Patricia Pérez, Guillermo Albericio, Mariano Esteban, Juan García-Arriaza, Juan J. Lasarte, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Current vaccines against SARS-CoV-2, based on the original Wuhan sequence, induce antibodies with different degrees of cross-recognition of new viral variants of concern. Despite potent responses generated in vaccinated and infected individuals, the
Externí odkaz:
https://doaj.org/article/d6eeb1262c3448e28351a2b77e173722
Autor:
Belén Aparicio, David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Patrick Theunissen, Ibon Tamayo, Cristian Smerdou, Ana Igea, Marta Santisteban, Cristina Gónzalez-Deza, Juan J. Lasarte, Sandra Hervás-Stubbs, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the development of more potent strategies. Combination of ICI with vaccination strategies would enhance
Externí odkaz:
https://doaj.org/article/3a2ee2360ef7461b9bdbb51a0147e8e8
Autor:
David Repáraz, Marta Ruiz, Leyre Silva, Belén Aparicio, Josune Egea, Elizabeth Guruceaga, Daniel Ajona, Yaiza Senent, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Sandra Hervás-Stubbs, Juan José Lasarte, Diana Llopiz, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive den
Externí odkaz:
https://doaj.org/article/53cc78736e214f2f9fa14856330d5191
Autor:
Kathrin Heim, Maike Hofmann, Robert Thimme, Marta Ruiz, Pablo Sarobe, Sandra Hervás-Stubbs, Bruno Sangro, Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte, David Repáraz, Enric Vercher, Diana Llopiz, Leyre Silva, Belén Aparicio, Josune Egea, Ibon Tamayo-Uria, Jorge García-Balduz, Carla Castro, Mercedes Iñarrairaegui, Charlotte Rohrer, Catrin Tauber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. Hepatocellular carcinoma (HCC) is a moderately mutated tumor, wh
Externí odkaz:
https://doaj.org/article/e75aa63eaad841d5bb0638f521590de1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor
Externí odkaz:
https://doaj.org/article/0081d4676bc442c9838910660c2e8051
Autor:
Lorea Villanueva, Leyre Silva, Diana Llopiz, Marta Ruiz, Tamara Iglesias, Teresa Lozano, Noelia Casares, Sandra Hervas-Stubbs, María José Rodríguez, José L. Carrascosa, Juan José Lasarte, Pablo Sarobe
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Tumor infiltrating lymphocytes have been associated with a better prognostic and with higher response rates in patients treated with checkpoint inhibiting antibodies, suggesting that strategies promoting tumor inflammation may enhance the efficacy of
Externí odkaz:
https://doaj.org/article/5a45009c311643a2aa613f6bc060200e
Autor:
Aintzane Zabaleta, Delia D'Avola, Itziar Echeverria, Diana Llopiz, Leyre Silva, Lorea Villanueva, José Ignacio Riezu-Boj, Esther Larrea, Alexander Pereboev, Juan José Lasarte, Iago Rodriguez-Lago, Mercedes Iñarrairaegui, Bruno Sangro, Jesús Prieto, Pablo Sarobe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
The lack of antiviral cellular immune responses in patients with chronic hepatitis C virus (HCV) infection suggests that T-cell vaccines may provide therapeutic benefit. Due to the central role that dendritic cells (DC) play in the activation of T-ce
Externí odkaz:
https://doaj.org/article/a824b1a51cd6450d8b80d26a263f2b52
Autor:
Alfonso Calvo, Jay A. Berzofsky, Pablo Sarobe, David F. Stroncek, Josune Egea, David Repáraz, Esther Redin, Belén Aparicio, Juan José Lasarte, Leyre Silva, Matthew Angel, Diana Llopiz, Marta Ruiz
Publikováno v:
Cancer Lett
Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a subset with poorer immunogenicity and clinical efficacy. Inhibitory TAM receptors MER and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4ac0bb08ded356129b4b9d130903f
https://doi.org/10.1016/j.canlet.2020.11.022
https://doi.org/10.1016/j.canlet.2020.11.022
Autor:
David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Belén Aparicio, Josune Egea, Ibon Tamayo-Uria, Sandra Hervás-Stubbs, Jorge García-Balduz, Carla Castro, Mercedes Iñarrairaegui, Maria Tagliamonte, Angela Mauriello, Beatrice Cavalluzzo, Luigi Buonaguro, Charlotte Rohrer, Kathrin Heim, Catrin Tauber, Maike Hofmann, Robert Thimme, Bruno Sangro, Pablo Sarobe
Publikováno v:
Journal for immunotherapy of cancer. 10(2)
BackgroundNeoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. Hepatocellular carcinoma (HCC) is a moderately mutated tumor, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472a8fe45dc4a563b320a4479727e25f
https://pubmed.ncbi.nlm.nih.gov/35193931
https://pubmed.ncbi.nlm.nih.gov/35193931