Up-regulation of CB1 cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat

Autor: Leyre Echeazarra, Sergio Barrondo, Gontzal García del Caño, Itziar Bonilla-Del Río, Jon Egaña-Huguet, Nagore Puente, Xabier Aretxabala, Mario Montaña, Maider López de Jesús, Imanol González-Burguera, Miquel Saumell-Esnaola, María Aránzazu Goicolea, Pedro Grandes, Joan Sallés

Publikováno v: Frontiers in Neuroanatomy, Vol 16 (2022)

The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate Gi/o proteins in the medial prefr

Externí odkaz: https://doaj.org/article/70efecff7f434c68b2dafd26fc181ffd

Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry

Autor: Leyre Echeazarra, Maria Pura Hortigón-Vinagre, Oscar Casis, Mónica Gallego

Publikováno v: Frontiers in Physiology, Vol 11 (2021)

The electrophysiological behavior of the zebrafish heart is very similar to that of the human heart. In fact, most of the genes that codify the channels and regulatory proteins required for human cardiac function have their orthologs in the zebrafish

Externí odkaz: https://doaj.org/article/bdc9cbad93a348d5b0fa703c498aacf7

Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1

Autor: Maider López de Jesús, Susana Mato, Sergio Barrondo, Xabier Aretxabala, Miquel Saumell-Esnaola, Catherine Ledent, Leire Borrega-Roman, Carlos Matute, Leyre Echeazarra, M.A. Goicolea, Imanol González-Burguera, Gontzal García del Caño, Joan Sallés

Publikováno v: Histochemistry and Cell Biology

Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low performance of antibodies r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b730cb3584196109ce4dc19d22f8d
http://europepmc.org/articles/PMC8604870

Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart

Autor: Layse Malagueta-Vieira, Julieta Fernández-Ruocco, María P. Hortigón-Vinagre, Víctor Zamora, Julián Zayas-Arrabal, Leyre Echeazarra, Godfrey L. Smith, Martín Vila Petroff, Emiliano Medei, Óscar Casis, Mónica Gallego

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6021

Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and sudden cardiac death, and met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e938af3b82de9b2ba3a61a11c54c46
https://pubmed.ncbi.nlm.nih.gov/35682699

CaMKII Modulates the Cardiac Transient Outward K+ Current through its Association with Kv4 Channels in Non-Caveolar Membrane Rafts

Autor: Janire Urrutia, Oscar Casis, Aintzane Alday, Mónica Gallego, Victor Fernández-López, Leyre Echeazarra, Hasna Ahyayauch

Publikováno v: Cellular Physiology and Biochemistry, Vol 54, Iss 1, Pp 27-39 (2020)

Background/aims To test whether the physiological regulation of the cardiac Kv4 channels by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in rat cardiomyocytes also occur i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cebb877b499e674995c7b96c24730c2
https://doi.org/10.33594/000000203