Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leyma P. De Haro"'
Autor:
Karlett J. Parra, Catherine Prudom, Sahba Charkhzarrin, Summer M. Raines, Larry A. Sklar, Chun-Yuan Chan, Sandra D. Melman, Chris Allen, Leyma P. De Haro, Samuel A. Lee
Publikováno v:
Journal of Biological Chemistry. 287:10236-10250
Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we conducted a high-throughput screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdb30be80ce28feef6f94c69bb816fb
https://doi.org/10.1074/jbc.m111.321133
https://doi.org/10.1074/jbc.m111.321133
Publikováno v:
Current Opinion in Hematology. 15:338-345
Purpose of review This review highlights recent findings about the known DNA repair machinery, its impact on chromosomal translocation mechanisms and their relevance to leukemia in the clinic. Recent findings Chromosomal translocations regulate the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1aa3a9274c095fc26c666b5ba3e9069
https://doi.org/10.1097/moh.0b013e328302f711
https://doi.org/10.1097/moh.0b013e328302f711
Autor:
Hsin-Chih Yeh, Jennifer S. Martinez, Mary E. Phipps, Evan P. Perillo, Douglas P. Shepherd, Andrew K. Dunn, Leyma P. De Haro, James H. Werner
Publikováno v:
SPIE Proceedings.
Here we present an automated microscope capable of 3D multi-color single molecule localization of individual messenger RNA molecules in a wide range of cell types. We have implemented astigmatic imaging with a cylindrical lens to improve z-localizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3f4d14d0ff32440a45ef4f6b8cdffc8
https://doi.org/10.1117/12.2038197
https://doi.org/10.1117/12.2038197
Autor:
Jac A. Nickoloff, Mark A. Brenneman, Montaser Shaheen, Robert Hromas, Suk Hee Lee, Leyma P. De Haro, Elizabeth A. Williamson, Krishnan Radhakrishnan, Justin Wray, Sheema Fnu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(2)
Given its significant role in the maintenance of genomic stability, histone methylation has been postulated to regulate DNA repair. Histone methylation mediates localization of 53BP1 to a DNA double-strand break (DSB) during homologous recombination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abe15464e4b471163aab826fb19a711
https://pubmed.ncbi.nlm.nih.gov/21187428
https://pubmed.ncbi.nlm.nih.gov/21187428
Autor:
Neil Osheroff, Elizabeth A. Williamson, Amanda C. Gentry, Robert Hromas, Justin Wray, Leyma P. De Haro, Jac A. Nickoloff, Stephen T. Durant, Lori Kwan Corwin, Suk Hee Lee
Publikováno v:
Nucleic Acids Research
Metnase is a human protein with methylase (SET) and nuclease domains that is widely expressed, especially in proliferating tissues. Metnase promotes non-homologous end-joining (NHEJ), and knockdown causes mild hypersensitivity to ionizing radiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c2cc1d05fe46e8f205eefe809931d8
https://pubmed.ncbi.nlm.nih.gov/20457750
https://pubmed.ncbi.nlm.nih.gov/20457750
Autor:
Cheryl A. Miller, Benjamin P C Chen, David J. Chen, Stephen T. Durant, Jac A. Nickoloff, Meena Shrivastav, Leyma P. De Haro
DNA double-strand breaks (DSBs) are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). The NHEJ/HR decision is under complex regulation and involves DNA-dependent protein kinase (DNA-PKcs). HR is elevated in DNA-PKcs null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56574892310e9029ad9cc9db1df73673
https://europepmc.org/articles/PMC3071034/
https://europepmc.org/articles/PMC3071034/
Publikováno v:
Cell research. 18(1)
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide variety of genetic alterations including large- or small-scale deletions, loss of heterozygosity, translocations, and chromosome loss. DSBs are repaired by n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadc5d1307c4b6d211fd4dfc12fb390e
https://pubmed.ncbi.nlm.nih.gov/18157161
https://pubmed.ncbi.nlm.nih.gov/18157161