Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Leyla H. Sharaf"'
Autor:
Nada A. Al-Hasawi, Sanaa A. Amine, Leyla H. Sharaf, Ladislav Novotny, Oludotun A. Phillips, Fatma H. Al-Awadhi
Publikováno v:
Anticancer research. 40(9)
BACKGROUND/AIM Neuroblastoma (NB), the most common extracranial malignant childhood tumor accounts for about 15% of cancer-related deaths in children. Despite the intensive treatment of patients with high-risk scarification of NB, clinical outcomes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cad50a9e1697293cf6858765ff11c95
https://pubmed.ncbi.nlm.nih.gov/32878801
https://pubmed.ncbi.nlm.nih.gov/32878801
Publikováno v:
General physiology and biophysics. 37:93-99
Triorganotins belong to toxic components present predominantly in antifouling paints for marine vessels. Tributyltin/triphenyltin at pico- or nanomolar concentrations in sea water are known to induce an irreversible sexual abnormality in females of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10886b9c286e5ce9e16fbf557a19dcc3
https://doi.org/10.4149/gpb_2017051
https://doi.org/10.4149/gpb_2017051
Autor:
Roselyn Jennifer D’silva, Leyla H. Sharaf, Ludmil Benov, Oludotun A. Phillips, D. Eric Walters, Teklu O. Bahta, Edet E. Udo
Publikováno v:
European Journal of Medicinal Chemistry. 106:120-131
Research activities on the oxazolidinone antibacterial class of compounds continue to focus on developing newer derivatives with improved potency, broad-spectrum activity and safety profiles superior to linezolid. Among the safety concerns with the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d489e18385ba88bca84cca3d6b34cf
https://doi.org/10.1016/j.ejmech.2015.10.025
https://doi.org/10.1016/j.ejmech.2015.10.025
Publikováno v:
European Journal of Pharmaceutical Sciences. 71:56-61
Oxazolidinone class of compounds continue to generate interest as promising agents effective against sensitive and resistant Gram-positive pathogenic bacteria strains. Recent focus is to develop new potent derivatives with improved broad-spectrum act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6adb193a0e944e5d32ac227dfe41b8
https://doi.org/10.1016/j.ejps.2015.02.006
https://doi.org/10.1016/j.ejps.2015.02.006
Autor:
Leyla H. Sharaf, Oludotun A. Phillips
Publikováno v:
Expert opinion on therapeutic patents. 26(5)
Antimicrobial resistance in Gram-positive bacteria is a major health care issue. This review summarizes patent publications from 2012 to 2015 that divulged novel oxazolidinones as antibacterial agents.A total of 25 patents obtained from Espacenet, WI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85764d8f17cf39ec1697561a693943b1
https://pubmed.ncbi.nlm.nih.gov/26998627
https://pubmed.ncbi.nlm.nih.gov/26998627
Autor:
Leyla H. Sharaf, Oludotun A. Phillips
Publikováno v:
Expert Opinion on Therapeutic Patents. 19:529-540
The application, WO2008062379, claims chimeric compounds comprising chemically linked 5-hydroxymethyl-oxazolidinone and tetracyclic-quinolone moieties. The claimed compounds are potent expanded-range antibacterial agents against selected gram-positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed49bdc6e876dce71750ebcb2afc287
https://doi.org/10.1517/17530050902800142
https://doi.org/10.1517/17530050902800142
Publikováno v:
International journal of oncology. 38(5)
Both de novo and acquired endocrine resistance constitute a major therapeutic problem for treatment of hormone-positive breast cancer. Multiple explanatory mechanisms have been proposed through the study of cellular models which focus principally on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458e63415d2a988d8e8b578912d04912
https://pubmed.ncbi.nlm.nih.gov/21318221
https://pubmed.ncbi.nlm.nih.gov/21318221
Publikováno v:
Journal of Urology. 183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::427aa21df573ecca0242c3f7b4050b82
https://doi.org/10.1016/j.juro.2010.02.1487
https://doi.org/10.1016/j.juro.2010.02.1487
Publikováno v:
Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 20(1)
Objectives: To evaluate the stability of 12 triazolyl oxazolidinone (TOZ) derivatives in simulated gastric and intestinal fluids as well as in human plasma at 37 ± 1°C. Materials and Methods: A stability-indicating high-performance liquid chromatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07f4633aeb105366fcad19e837d6723
https://pubmed.ncbi.nlm.nih.gov/21160215
https://pubmed.ncbi.nlm.nih.gov/21160215