Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Leyla Fouani"'
Autor:
Sharleen V. Menezes, Bekesho Geleta, Leyla Fouani, Des R. Richardson, Michael L.-H. Huang, Sanaz Maleki, Alexander Richardson, Zaklina Kovacevic
Publikováno v:
Carcinogenesis. 40:805-818
The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhi
Publikováno v:
Pharmacological Research. 115:275-287
Metastasis is currently the leading cause of cancer related death and is the most feared and difficult to treat outcome for cancer patients. This complex process is regulated by a plethora of signaling pathways and molecules that control cell prolife
Autor:
Louise Cole, Des R. Richardson, Michael L.-H. Huang, Patric J. Jansson, Leyla Fouani, Zaklina Kovacevic
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118673
Microtubules are polymers of α/β-tubulin, with microtubule organization being regulated by microtubule-associated proteins (MAPs). Herein, we describe a novel role for the epithelial gene repressor, zinc finger E-box-binding homeobox 1 (ZEB1), that
Autor:
Leyla Fouani, Patric J. Jansson, Des R. Richardson, Zaklina Kovacevic, Darius J.R. Lane, Sumit Sahni, Nicole A. Seebacher, Angelica M. Merlot, Danuta S. Kalinowski
Publikováno v:
Pharmacological Research. 100:255-260
Cancer is a disease that is a "moving target", since as the condition progresses, the molecular targets change and evolve. Moreover, due to clonal selection, a specific anti-cancer drug with one molecular target may only be effective for a limited ti
Autor:
Ruxing Xi, Xiaozhi Zhang, Danuta S. Kalinowski, Sharleen V. Menezes, Ivan Ho Yuen Pun, Leyla Fouani, Michael L.H. Huang, Des R. Richardson, Zaklina Kovacevic
Publikováno v:
Molecular pharmacology. 91(5)
Tumor necrosis factor α (TNFα) plays a vital role in cancer progression as it is associated with inflammation and promotion of cancer angiogenesis and metastasis. The effects of TNFα are mediated by its downstream target, the oncogene lysine-rich
Autor:
Des R. Richardson, Danson Wooi, Hiu Chuen Lok, Duraippandi Palanimuthu, Leyla Fouani, Patric J. Jansson, Sumit Sahni, Danuta S. Kalinowski, Kyung Chan Park, Darius J.R. Lane, Michael L.-H. Huang, Zaklina Kovacevic
Publikováno v:
Metallomics : integrated biometal science. 8(9)
Copper is an essential trace metal required by organisms to perform a number of important biological processes. Copper readily cycles between its reduced Cu(i) and oxidised Cu(ii) states, which makes it redox active in biological systems. This redox-