Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Leyi Gong"'
Publikováno v:
Traditional Medicine Research. 7:10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e402058369eb3ea5735dc8666965706c
https://doi.org/10.53388/tmr20220207263
https://doi.org/10.53388/tmr20220207263
Autor:
Tran Tran, Karen Matsuyama, Leyi Gong, Isha Soni, Manjulika Shukla, Sidharth Chopra, Mary J. Tanga
Publikováno v:
International Journal of Antimicrobial Agents. 52:22-27
Multidrug-resistant Acinetobacter baumannii (MDR-Ab) is one of the most significant nosocomial pathogens that is being increasingly isolated in healthcare settings worldwide. Owing to its inherent drug-resistant nature, coupled with its ability to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf1474392492b2709fdc8e4556dda26
https://doi.org/10.1016/j.ijantimicag.2018.02.018
https://doi.org/10.1016/j.ijantimicag.2018.02.018
Autor:
Taygerly Joshua Paul Gergely, Eun Kyung Lee, Mcintosh Joel, Sarah C. Abbot, Jaehyeon Park, Sonal Rajyaguru, Yun-Chou Tan, Shalini Anand, Francisco Xavier Talamas, Sophie Le Pogam, Remy Lemoine, David S. Carter, Petra Inbar, Jun Chen, Leanna R. Staben, Armando G. Villaseñor, Javier de Vicente, Isabel Najera, Ryan Craig Schoenfeld, Leyi Gong, Seth F. Harris, Paul Weller, Sharada Shenvi Labadie, Ken A. Brameld, Aruna Railkar, Sangi Michael, Amy Fung, Jim Li, Vincent Leveque, Dana Davis
Publikováno v:
Journal of Medicinal Chemistry. 57:1914-1931
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b3c89c500a0233782f42b5f71c4d4
https://doi.org/10.1021/jm401329s
https://doi.org/10.1021/jm401329s
Autor:
R. Ursula Kammlott, Deborah Carol Reuter, Teresa Alejandra Trejo-Martin, Leyi Gong, Christophe Michoud, Andreas Kuglstatter, Patricia Tran, David Michael Goldstein, Yun-Chou Tan, Parcharee Tivitmahaisoon, Linghao Niu, Shao-Yong Wu, Sue Jin, Paul Weller, Gary Hsieh, Karin Ann Stein, Humberto Bartolome Arzeno, James Patrick Dunn, Ada Shao, Wylie Solang Palmer, J. Heather Hogg, Johannes C. Hermann, Kung-ching Chang, Bindu Goyal, Alam Jahangir, Cheryl Janson, Tania Silva, Christine Lukacs, Paul J. Wagner, Muzaffar Alam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1486-1492
A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b003a69164deb7db8c54e3d4d75bb7b
https://doi.org/10.1016/j.bmcl.2012.12.047
https://doi.org/10.1016/j.bmcl.2012.12.047
Publikováno v:
British Journal of Pharmacology. 165:1124-1136
BACKGROUND AND PURPOSE It is thought that the anti-inflammatory effects of glucocorticoids (GCs) are largely due to GC receptor (GR)-mediated transrepression of NF-κB and other transcription factors, whereas side effects are caused by activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bdf19113330438bbdfb78dc9620cb78
https://doi.org/10.1111/j.1476-5381.2011.01574.x
https://doi.org/10.1111/j.1476-5381.2011.01574.x
Autor:
Leyi Gong, Robert S Wilhelm
Publikováno v:
Expert Opinion on Therapeutic Patents. 19:1109-1132
Background: Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease. Objectives/methods: A patent literature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40d297aeb77d665b25fa2a3a575b87c
https://doi.org/10.1517/13543770903008544
https://doi.org/10.1517/13543770903008544
Autor:
Leyi Gong, Surendra Kumar Nayak, Bejan Rasoul, Willma Polgar, Wei Zhou, Amina S Adem, William J Thomsen
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68da50d8874229706f2ed51fca903f79
https://doi.org/10.1096/fasebj.27.1_supplement.655.9
https://doi.org/10.1096/fasebj.27.1_supplement.655.9
Autor:
Xiaochun Han, Yun-Chou Tan, Sue Jin, Paul J. Wagner, Alejandra Trejo, Parch Tivitmahaisoon, David Mark Rotstein, Bindu Goyal, Andreas Kuglstatter, Wylie Solang Palmer, Leyi Gong, Brian Wong, Patricia Tran, Alam Jahagir, Alice Chang, Joseph Dal Porto, Linghao Niu, Johaness Hermann, Fengrong Zuo, James Patrick Dunn, Karin Ann Stein, Heather Hogg, Muzaffar Alam, Ada Shao, David Michael Goldstein, Deborah Carol Reuter, Ferenc Makra, Gary Hsieh, Brad Loe, Lubov Filonova, Lubica Rapatova, Tania Silva
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(12)
A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs. Structure guided design was used to optimize the series resulting in a signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1d571f35d6a4f78286cd06b8fa7d5d
https://pubmed.ncbi.nlm.nih.gov/23664880
https://pubmed.ncbi.nlm.nih.gov/23664880
Autor:
Leyi Gong, Howard Parnes
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:425-433
The preparation of the title compound, a selective 5-HT 3 antagonist with anti-emetic properties, is described. The key intermediate involved is 6-bromo-1,2-dihydronaphthoic acid (5), which was synthesized from 4-bromophenylacetic acid by Micheal add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdfb949798299ba6266b336de9333fd7
https://doi.org/10.1002/(sici)1099-1344(199605)38:5<425::aid-jlcr860>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199605)38:5<425::aid-jlcr860>3.0.co
Autor:
Leyi Gong, Howard Parnes
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:31-40
We describe herein the synthesis of polybromodiphenylacetic acid (4), a fragment common to the tritiation substrates (8) and (11) of the sodium channel blocker, PD-85639 (1) and the angiotensin II inhibitor EXP-655 (2) respectively. Preparation of (8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556306d573723f6b50bca26b20a69dbf
https://doi.org/10.1002/(sici)1099-1344(199601)38:1<31::aid-jlcr806>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199601)38:1<31::aid-jlcr806>3.0.co