Zobrazeno 1 - 10
of 592
pro vyhledávání: '"Ley SV"'
Publikováno v:
Tetrahedron. 73(14):1812-1819
Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7e87f987b19dff4a7296883623d089
Autor:
Godineau, E, Battilocchio, C, Lehmann, M, Ley, SV, Labes, R, Birnoschi, L, Subramanian, S, Prasanna, CS, Gorde, A, Kalbagh, M, Khade, V, Scherrer, A, O'sullivan, ACC
We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a55e06faf83e157843bfe5d0ff00477
Autor:
Ley, SV, Godineau, Edouard, Battilocchio, Claudio, Lehmann, Matthias, Labes, Ricardo, Birnoschi, Letitia, Subramanian, Srinivas, Prasanna, CS, Gorde, Amol, Kalbagh, Mahesh, Khade, Vivek, Scherrer, Anton, O'Sullivan, Anthony Cornelius
We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06904d772074f9918a835ef431b49f3
Autor:
Ley, SV, O'Brien, Matthew
A mannitol derived 2,3-butanediacetal ethyl ketone displays high levels of diastereoselectivity in boron and titanium mediated aldol reactions with a range of aliphatic and aromatic aldehydes to afford syn aldol products in high yield. The stereochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956e22d4dba6985e6220cbe3b36d1bcb
A new three-component coupling protocol for preparation of functionalized indolines, with a high degree of diastereoselectivity, has been developed. The protocol is based on the in situ homologation of vinyl boronic acids to allylboronic acids, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a2565cdb08386b323cce3ef7d58c4a
Autor:
Fitzpatrick, DE, Ley, SV
Synthesis is changing in response to our modern resource conscious world. The principles of green chemistry are evolving as the interfaces and boundaries in science are less obvious and providing a new stimuli for future discovery. The invention and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22aa4f256368c753331fafeae5b9cb32
https://www.repository.cam.ac.uk/handle/1810/268026
https://www.repository.cam.ac.uk/handle/1810/268026
Publikováno v:
Reaction Chemistry & Engineering
A new bespoke semi-continuous parallel column supercritical fluid chromatography unit has been developed that solves the problem of effective separation of continuous, multicomponent reaction mixtures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64be467223a4fcd4b69347a32dea6f3a
Autor:
Labes, R, Battilocchio, C, Mateos, C, Cumming, GR, de Frutos, O, Rincón, JA, Binder, K, Ley, SV
A continuous flow method for the selective oxidation of secondary alcohols is reported. The method is based on an Oppenauer-type ruthenium-catalyzed hydrogen-transfer process that uses acetone as both solvent and oxidant. The process utilizes a low l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6b237a03fbc88ad3afea989ee87df2
We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e80d4328bfa6e2a7147560e112c740
Autor:
labes, R, Calderon, DG, Battilocchio, C, Mateos, C, Cumming, GR, de Frutos, O, Rincon, JA, Ley, SV
A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d9ae6efd0b0905402c38870dd7facf