Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Autor: Yiguo Shen, David Kapfhamer, Angela M. Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley Hian Low, Stephen M. Massa, Raymond A. Swanson

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD

Externí odkaz: https://doaj.org/article/497cdfb0e4284c52930bb8c6a8bbcb88

PTEN secretion in exosomes

Autor: Jason Howitt, Ulrich Putz, Sophia Mah, Ley-Hian Low, Seong-Seng Tan, Choo-Peng Goh

Publikováno v: Methods. :157-163

PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a62d52db5b9e4f75132caed3b6b7e6
https://doi.org/10.1016/j.ymeth.2014.12.016

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Autor: Stephen M. Massa, Raymond A. Swanson, Yanting Chen, Yong Huang, Ji-Eun Kim, Seok Joon Won, Angela M. Minnella, Ley-Hian Low, Yiguo Shen, David Kapfhamer

Publikováno v: Shen, Y; Kapfhamer, D; Minnella, AM; Kim, J-E; Won, SJ; Chen, Y; et al.(2017). Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. NATURE COMMUNICATIONS, 8, 624. doi: 10.1038/s41467-017-00707-0. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1sz7m11h
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature communications, vol 8, iss 1
Nature Communications

The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5531bbd4080d13eb5d089e09acc8a0
http://www.escholarship.org/uc/item/1sz7m11h

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development

Autor: Jason Howitt, Jenny M. Gunnersen, Vicki E. Hammond, Ulrich Putz, Seong-Seng Tan, Choo-Peng Goh, Ley-Hian Low

Publikováno v: Neuroscience Letters. 555:225-230

During development, protein substrates need to be removed and degraded when they are no longer required. The E3 ubiquitin ligases, including Nedd4 family proteins, are a major group of enzymes responsible for adding ubiquitin chains to protein substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50addd32563c7f828d35357a3659efff
https://doi.org/10.1016/j.neulet.2013.09.017

Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking

Autor: Yijia, Li, Ley-Hian, Low, Ulrich, Putz, Choo-Peng, Goh, Seong-Seng, Tan, Jason, Howitt

Publikováno v: Traffic (Copenhagen, Denmark). 15(7)

The spatial regulation of Pten is critical for its role as a tumour suppressor with both nuclear and cytoplasmic locations being implicated with distinct functions. In the cytoplasm, Pten plays a central role in opposing PI3K/Akt cell signalling, whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6722213dad08783811b0df37cedd6149
https://pubmed.ncbi.nlm.nih.gov/24798731