Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Lexitropsin"'
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 26:217-233
1- and 1,5-Aminoalkylamine substituted anthraquinones (AAQs, 1C3 and 1,5C3) were peptide coupled to 1-, 2-, and 3-pyrrole lexitropsins to generate compounds that incorporated both DNA minor groove and intercalating moieties. The corresponding platinu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d85593c65c3a8b0fd05c31dba7552c8
https://doi.org/10.1007/s00775-020-01847-3
https://doi.org/10.1007/s00775-020-01847-3
Publikováno v:
Dalton Transactions. 50:17945-17952
Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(II) moieties attached were developed with the goal of generating novel DNA binding modes, including the targeting of AT-rich regions in order to have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9162356716481d0c11d9f74bc891ecec
https://doi.org/10.1039/d1dt03539h
https://doi.org/10.1039/d1dt03539h
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Rajeev Ahuja, Yogendra Kumar Mishra, Hasan Alniss, John Parkinson, Mohammad H. Semreen, Pritam Kumar Panda, Ini-Isabée Witzel
Publikováno v:
Journal of Medicinal Chemistry. 62:10423-10440
Lexitropsins are small molecules that bind to the minor groove of DNA as antiparallel dimers in a specific orientation. These molecules have shown therapeutic potential in the treatment of several diseases; however, the development of these molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc602be587918adbe8bd6537051b5da4
https://doi.org/10.1021/acs.jmedchem.9b01534
https://doi.org/10.1021/acs.jmedchem.9b01534
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 19:98-113
The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706666382716d31fc73047eab83c1dea
https://doi.org/10.2174/1389557518666181009143203
https://doi.org/10.2174/1389557518666181009143203
Publikováno v:
Biophysics. 62:876-884
Molecular-modeling methods have been used to perform energy analysis of dimeric complex formation between lexitropsins and double-stranded DNA. Stabilization of dimeric complexes by hydrophobic and van der Waals interactions has been demonstrated. El
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1ec809d27ccce0d353236cd1f6d9e8f
https://doi.org/10.1134/s0006350917060100
https://doi.org/10.1134/s0006350917060100
Autor:
Y.-Y. Fang, W.M. Southerland
A critical factor in the design of effective drugs is the specificity of the drug/target interaction. In the case of genome-based drug design, the double helical structure of DNA provides three binding mode opportunities for potential ligands. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece9b70353f055a375a438ebdc98c427
https://doi.org/10.1016/b978-0-12-409548-9.11745-2
https://doi.org/10.1016/b978-0-12-409548-9.11745-2
Autor:
Linda Cerofolini, Marco Fragai, Valentina Borsi, Bruno Pagano, Antonio Randazzo, Jussara Amato
Publikováno v:
Journal of Molecular Recognition. 28:376-384
DNA-minor-groove-binding ligands are potent antineoplastic molecules. The antibiotic distamycin A is the prototype of one class of these DNA-interfering molecules that have been largely used in vitro. The affinity of distamycin A for DNA is well know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14d0487d3aad0a84d16fe4ea247cd01
https://doi.org/10.1002/jmr.2452
https://doi.org/10.1002/jmr.2452
Autor:
Elise Champeil, Anne-Marie Sapse
Publikováno v:
Comptes Rendus Chimie. 17:1190-1196
We have constructed hybrid drugs where mitomycin C is linked to the N -methylpyrrole carboxamide framework present in lexitropsins. The coupling reactions leading to these products are efficient and the yields are very high. An interesting spectrosco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e42b7ffb95e4ea198b73c306f505767e
https://doi.org/10.1016/j.crci.2014.03.004
https://doi.org/10.1016/j.crci.2014.03.004
Autor:
Danuta Drozdowska, Jakub Szerszenowicz
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 11300-11315 (2014)
Molecules; Volume 19; Issue 8; Pages: 11300-11315
Molecules
Molecules; Volume 19; Issue 8; Pages: 11300-11315
Molecules
A general route for the semi-automatic synthesis of some new potential minor groove binders was established. Six four-numbered sub-libraries of new netropsin and bis-netropsin analogues have been synthesized using a Syncore Reactor. The structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b3587cde4f5fb62e33535b07eee1aa
http://www.mdpi.com/1420-3049/19/8/11300
http://www.mdpi.com/1420-3049/19/8/11300