Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Lewy pathology"'
Autor:
Hsin-Pei Wang, Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Z. Huie, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Dan M. Mungas, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrep
Externí odkaz:
https://doaj.org/article/2ccca9693bd8481a91ee168a49211a38
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-onset, autosomal dominant Parkinson’s disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease in families wit
Externí odkaz:
https://doaj.org/article/da2c58a1ae9843f98d0d8b3b915e5228
Akademický článek
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Akademický článek
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Autor:
Sandra Villar-Conde, Veronica Astillero-Lopez, Melania Gonzalez-Rodriguez, Daniel Saiz-Sanchez, Isabel Ubeda-Banon, Alicia Flores-Cuadrado, Alino Martinez-Marcos
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
Hyposmia is one of the prodromal symptoms of Parkinson’s disease (PD) and a red flag in clinical diagnosis. Neuropathologically, this sign correlates with α-synuclein involvement in the anterior olfactory nucleus (AON). Neurodegeneration, microgli
Externí odkaz:
https://doaj.org/article/ddb2aee4a8a94756ac067bb3e07043ce
Autor:
Michael X. Henderson, Martin T. Henrich, Fanni F. Geibl, Wolfgang H. Oertel, Patrik Brundin, D. James Surmeier
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105687- (2022)
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor dysfunction is only one of many symptoms experienced by patients. A neuropathol
Externí odkaz:
https://doaj.org/article/3075f51f2b2048088a525a1df8495813
Autor:
H. Geut, D. H. Hepp, E. Foncke, H. W. Berendse, J. M. Rozemuller, I. Huitinga, W. D. J. van de Berg
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract The clinical diagnosis in patients with parkinsonian disorders can be challenging, and a definite diagnosis requires neuropathological confirmation. The aim of this study was to examine whether a clinical diagnosis of Parkinson’s disease (
Externí odkaz:
https://doaj.org/article/f145f8fa56da4976b7f79055c457f90f
Autor:
Leah J. Weston, Anna M. Bowman, Valerie R. Osterberg, Charles K. Meshul, Randall L. Woltjer, Vivek K. Unni
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15294 (2022)
Alpha-synuclein (aSyn) is a 14 kD protein encoded by the SNCA gene that is expressed in vertebrates and normally localizes to presynaptic terminals and the nucleus. aSyn forms pathological intracellular aggregates that typify a group of important neu
Externí odkaz:
https://doaj.org/article/e5f919137673410780444bdaa620ade1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical ani
Externí odkaz:
https://doaj.org/article/a660a87f78d84555a78d19f1217c76fb
Autor:
Daniel Twohig, Henrietta M. Nielsen
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-19 (2019)
Abstract The Alzheimer’s disease (AD) afflicted brain is neuropathologically defined by extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau protein. However, accumulating evidence sug
Externí odkaz:
https://doaj.org/article/1f903eb3d6d74479896c74c6e80dfa42