Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lewis W. Francis"'
Autor:
David W. James, Marcos Quintela, Lisa Lucini, Noor K. Alkafri, Gareth D. Healey, Kinza Younas, Adnan Bunkheila, Lavinia Margarit, Lewis W. Francis, Deyarina Gonzalez, R. Steven Conlan
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Decidualisation, the process whereby endometrial stromal cells undergo morphological and functional transformation in preparation for trophoblast invasion, is often disrupted in women with polycystic ovary syndrome (PCOS) resulting in complications w
Externí odkaz:
https://doaj.org/article/632dc9cfe14a49ed89a15573acdfcfd0
Autor:
Salvatore Vaiasicca, Gianmarco Melone, David W. James, Marcos Quintela, Alessandra Preziuso, Richard H. Finnell, Robert Steven Conlan, Lewis W. Francis, Bruna Corradetti
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background Down syndrome (DS) clinical multisystem condition is generally considered the result of a genetic imbalance generated by the extra copy of chromosome 21. Recent discoveries, however, demonstrate that the molecular mechanisms activ
Externí odkaz:
https://doaj.org/article/893ffeab788f49c1b46c45eede2c8f52
Autor:
Marcos Quintela, David W. James, Agne Pociute, Lydia Powell, Kadie Edwards, Zoe Coombes, Jetzabel Garcia, Neil Garton, Nagindra Das, Kerryn Lutchman-Singh, Lavinia Margarit, Amy L. Beynon, Inmaculada Rioja, Rab K. Prinjha, Nicola R. Harker, Deyarina Gonzalez, R. Steven Conlan, Lewis W. Francis
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD
Externí odkaz:
https://doaj.org/article/7e33d7221ca149fd99b604385784b7c0
Autor:
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102641- (2023)
At physiological levels, the trace element selenium plays a key role in redox reactions through the incorporation of selenocysteine in antioxidant enzymes. Selenium has also been evaluated as a potential anti-cancer agent, where selenium nanoparticle
Externí odkaz:
https://doaj.org/article/0d866209360b48c281dc8583dd5dbc1a
Autor:
Lydia C. Powell, Jennifer Y. M. Adams, Sadik Quoraishi, Charlène Py, Anaϊs Oger, Salvatore A. Gazze, Lewis W. Francis, Christopher von Ruhland, David Owens, Philip D. Rye, Katja E. Hill, Manon F. Pritchard, David W. Thomas
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundThe increasing prevalence of invasive fungal infections in immuno-compromised patients is a considerable cause of morbidity and mortality. With the rapid emergence of antifungal resistance and an inadequate pipeline of new therapies, novel
Externí odkaz:
https://doaj.org/article/15a722be6ea743308e6d0029bab58774
Autor:
David Howard, David James, Jezabel Garcia-Parra, Belen Pan-Castillo, Jenny Worthington, Nicole Williams, Zoe Coombes, Sophie Colleen Rees, Kerryn Lutchman-Singh, Lewis W. Francis, Paul Rees, Lavinia Margarit, R. Steven Conlan, Deyarina Gonzalez
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundOvarian cancer (OC) is amongst the most lethal of common cancers in women. Lacking in specific symptoms in the early stages, OC is predominantly diagnosed late when the disease has undergone metastatic spread and chemotherapy is relied on t
Externí odkaz:
https://doaj.org/article/be94b6891aff4b9ea06c5d408968e40c
Autor:
Lewis W. Francis, Seydou N. Yao, Lydia C. Powell, Sean Griffiths, Alexander Berquand, Thomas Piasecki, William Howe, Andrea S. Gazze, Mary C. Farach-Carson, Pamela Constantinou, Daniel Carson, Lavinia Margarit, Deya Gonzalez, R. Steven Conlan
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system. However, the adh
Externí odkaz:
https://doaj.org/article/5b74fbf0ce1748cc811e295453179805
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10098 (2021)
From the development of self-aggregating, scaffold-free multicellular spheroids to the inclusion of scaffold systems, 3D models have progressively increased in complexity to better mimic native tissues. The inclusion of a third dimension in cancer mo
Externí odkaz:
https://doaj.org/article/047079fc14ea4ee78f6f6286573f4be1
Autor:
Zara Ahmed, Lydia C. Powell, Navid Matin, Andrew Mearns-Spragg, Catherine A. Thornton, Ilyas M. Khan, Lewis W. Francis
Publikováno v:
Marine Drugs, Vol 19, Iss 8, p 405 (2021)
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million of the UK population. As the dense extracellular matrix of articular cartilage is primarily composed of col
Externí odkaz:
https://doaj.org/article/b1f4bf115947424d889841d8b9a23a22
Autor:
Yadan Zhang, Ben J. Morgan, Rachel Smith, Christopher R. Fellows, Catherine Thornton, Martyn Snow, Lewis W. Francis, Ilyas M. Khan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Platelet-rich plasma (PRP) is used to stimulate the repair of acute and chronic cartilage damage even though there is no definitive evidence of how this is achieved. Chondrocytes in injured and diseased situations frequently re-express pheno
Externí odkaz:
https://doaj.org/article/225b7d4c8d184455925e20069ae0a0cc