Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lewis S. Freedman"'
Publikováno v:
European Journal of Pharmacology. 24:366-374
Serum dopamine-β-hydroxylase activity is increased in rats after hypophysectomy. The maximal increase in serum hydroxylase activity occurs 2–4 weeks after hypophysectomy and reaches approximately 150% above the control values. ACTH, but not dexame
Publikováno v:
Biochemical Pharmacology. 23:924-929
Publisher Summary This chapter discusses the changes in human serum dopamine-β-hydroxylase activity in various physiological and pathological states. Dopamine-β-hydroxylase catalyses the β-hydroxylation of dopamine to norepinephrine; DβH is local
Publikováno v:
Life Sciences. 31:533-539
The radioligand 3 H-DHA was used to estimate the density and affinity of cardiac β-receptors in rat strains selectively bred for differences in response to stress. Maudsley Reactive rats selected for heightened reactivity to stress had a greater den
Publikováno v:
Behavior Genetics. 12:459-466
The Maudsley Reactive (MR) and Maudsley Non-Reactive (MNR) strains of rats, respectively selected by P. L. Broadhurst for high and low open-field defecation (OFD), were acquired by the National Institutes of Health in 1963 at the 21st generation of i
Publikováno v:
Pharmacology Biochemistry and Behavior. 17:187-191
Cycloheximide (CXM), a protein synthesis inhibitor, has been shown to result in a marked inhibition of central catecholamine (CA) synthetic mechanisms at doses that cause amnesia in animals. Unlike other inhibitors of CA synthesis no significant depl
Publikováno v:
Behavioral and Neural Biology. 34:319-325
Male rats of two Maudsley Nonreactive sublines, the MNRA/Har and MNR/Har strains, both selected for low levels of open-field defecation (OFD), exhibit higher concentrations of norepinephrine (NE) in descending and transverse colon than Maudsley React
Publikováno v:
Pharmacology Biochemistry and Behavior. 11:259-263
The role of noradrenergic (NE) me mechanisms in amnesia induced by the dopamine-β-hydroxylase (DBH) inhibitor, diethyldithiocarbamate (DEDTC) was examined by studying the antiamnestic characteristics of the alpha-NE receptor stimulator clonidine. DE
Publikováno v:
Proceedings of the National Academy of Sciences. 69:1883-1886
Dopamine-β-hydroxylase activity is present in mouse neuroblastoma C-1300 tumors. The activity is proportional to the weight of the tumor. Serum activity is markedly increased in mice that bear the tumors. Treatment of mice with 5-bromodeoxyuridine c
Autor:
Richard P. Ebstein, Dong H. Park, Menek Goldstein, Takeshi Ohuchi, Lewis S. Freedman, Stuart M. Levitz
Publikováno v:
Life Sciences. 13:769-774
A procedure for the radioimmunoassay of human circulatory dopamine-β-hydroxylase (DβH) using antibodies directed toward human DβH is described. A significant correlation between serum DβH activity and the amount of serum immunoreactive (IR) DβH
Publikováno v:
Life Sciences. 12:369-376
The acute and chronic swim stress led to an increase in serum dopamine-β-hydroxylase activity in rats. The elevated serum dopamine-β-hydroxylase levels found after stress probably reflect the balance between the rate of release and the rate of disa