Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lewis Klunk"'
Publikováno v:
Drug Metabolism and Disposition. 40:1308-1320
The exposure of a drug candidate and its metabolites in humans and preclinical species during drug development needs to be determined to ensure that the safety of drug-related components in humans is adequately assessed in the standard toxicology stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd9948556d6435b4151025f9ae813ff
https://doi.org/10.1124/dmd.112.044933
https://doi.org/10.1124/dmd.112.044933
Autor:
Chao Han, Sandhya Girish, Raymond Evers, Shiew-Mei Huang, Steven W. Martin, Hong Zhao, Lewis Klunk, Lei K. Zhang, Eva Gil Berglund, Honghui Zhou, Mark C. Peterson, Min Zhu, Joseph P. Balthasar, Amita Joshi
Publikováno v:
The AAPS Journal
Therapeutic proteins (TPs) are increasingly combined with small molecules and/or with other TPs. However preclinical tools and in vitro test systems for assessing drug interaction potential of TPs such as monoclonal antibodies, cytokines and cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93782684f5e1e495ffd90bacdcf54758
http://europepmc.org/articles/PMC3144367
http://europepmc.org/articles/PMC3144367
Autor:
Ellen Rohde, Aldo Costa, Ming Li, Shane Flannelly-King, Lawrence Gan, Judy Chou, Robin Caputo, Lewis Klunk, Hui Xu, Liyu Yang, Rajesh Mikkilineni, Jing Jing
Publikováno v:
Bioanalysis. 4(11)
Background: In recent years, there has been a growing interest in automating small-molecule bioanalytical sample preparations specifically using the Hamilton MicroLab® STAR liquid-handling platform. In the most extensive work reported thus far, mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3acc3d47e43aa4915b780993a4c9f32
https://pubmed.ncbi.nlm.nih.gov/22720650
https://pubmed.ncbi.nlm.nih.gov/22720650
Publikováno v:
Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::005faeec04d561960c12b5f5be5253d8
https://doi.org/10.1002/9780470929278.ch9
https://doi.org/10.1002/9780470929278.ch9
Publikováno v:
Biopharmaceuticsdrug disposition. 30(4)
The determination of metabolic pathways of a drug candidate through the identification of circulating and excreted metabolites is vitally important to understanding its physical and biological effects. Knowledge of metabolite profiles of a drug candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea45c0ccaaf22f31ba3c0332fc75c07c
https://pubmed.ncbi.nlm.nih.gov/19544285
https://pubmed.ncbi.nlm.nih.gov/19544285
Autor:
Donglu, Zhang, Marc, Ogan, Richard, Gedamke, Vikram, Roongta, Renke, Dai, Mingshe, Zhu, Kent, Rinehart J, Lewis, Klunk, James, Mitroka
Publikováno v:
Drug Metabolism and Disposition; July 2003, Vol. 31 Issue: 7 p837-45, 9p