Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lewis J. Stafford"'
Autor:
J Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J Stafford, Celine Cheng, Grant C Liao, Frederick W Holtsberg, M Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J Doranz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008730 (2020)
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Externí odkaz:
https://doaj.org/article/c7e7952329a2425385d3c09278e4276d
Autor:
Brad Screnci, Trevor Barnes, Kristen Shema, Rebecca Rimkunas, Shruthi Kannan, Tim Phillips, Carmen Navia, Charles Azuelos, Tom Charpentier, Jennifer Houtmann, Lisa Miller, Lewis J. Stafford, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers
Publikováno v:
Cancer Research. 82:317-317
Monoclonal antibodies (MAbs) are a well-established treatment approach in oncology and other diseases. Nevertheless, many multipass membrane proteins are largely inaccessible as antibody targets due to their poor expression, membrane-dependent struct
Autor:
Brad Screnci, Lewis J. Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Rimkunas, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Muprhy, Daniel B. Harmon, Tom Charpentier, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers
Publikováno v:
Cancer Research. 82:318-318
The tight junction protein Claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue, making it a valuable therapeutic target for many solid tumor cancers. Despite their potential as cancer therapeutics
Autor:
Brad Screnci, Lewis J. Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Wright, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Murphy, Daniel B. Harmon, Tom Charpentier, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers
Publikováno v:
iScience. 25:105665
The tight junction protein claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue. However, achieving therapeutic MAb specificity for this 4 transmembrane protein is challenging because it is nearly
Autor:
Edgar Davidson, J. Charles Whitbeck, M. Javad Aman, Graham Simmons, Lewis J. Stafford, Kathryn Kadash-Edmondson, Benjamin J. Doranz, Ariadna Grinyo-Escuer, Anu Thomas, Frederick W. Holtsberg, Grant C. Liao, Celine Cheng
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008730 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Autor:
Michael Brown, Lewis J Stafford, Dale Onisk, Tony Joaquim, Alhagie Tobb, Larissa Goldman, David Fancy, James Stave, Ross Chambers
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73255 (2013)
Tags are widely used to monitor a protein's expression level, interactions, protein trafficking, and localization. Membrane proteins are often tagged in their extracellular domains to allow discrimination between protein in the plasma membrane from t
Externí odkaz:
https://doaj.org/article/b5d08ce27c714ccba1f616fcfe0008bb
Publikováno v:
Cancer Research. 80:527-527
Monoclonal antibodies (MAbs) are a well-established treatment approach in oncology and other diseases. Nevertheless, multipass membrane proteins are largely inaccessible as MAb targets due to their poor expression, membrane-dependent structure, small
Autor:
Nicholas Molino, Chidananda Sulli, Benjamin J. Doranz, Lewis J. Stafford, Erin Rosenberg, Tom Charpentier, Ross Chambers, David F. Tucker, Joseph Rucker, Brad Screnci
Publikováno v:
Diabetes. 68
Integral membrane proteins are important drug targets, and monoclonal antibodies (mAbs) against them are highly sought for therapeutic and diagnostic purposes. However, the complex structure of multipass membrane proteins makes discovery of these mAb
Autor:
Rona Wilf, David F. Tucker, Sharon H. Willis, Joseph Rucker, Samantha Gilman, Tanmayee Hazarika, Ross Chambers, Jonathan Tabb Sullivan, Brad Screnci, Nicholas Molino, Trevor Barnes, Chidananda Sulli, Charpentier Thomas, Jennifer M. Pfaff, Erin Rosenberg, Rebecca Rimkunas, Benjamin J. Doranz, Lewis J. Stafford
Publikováno v:
Cancer Research. 78:5759-5759
Claudin 6 (CLDN6) is a tight junction molecule that is involved in cell to cell adhesion of epithelial and endothelial cell sheets. CLDN6 is considered an oncofetal protein which is not expressed in normal human tissue but is expressed in some cancer
Autor:
David F. Tucker, Sharon H. Willis, Ross Chambers, Lewis J. Stafford, Rachel H. Fong, Trevor Barnes, Nicholas Molino, Moniquetta Hall, Andrew Ettenger, Chidananda Sulli, Benjamin J. Doranz, Jennifer M. Pfaff, Brad Screnci, Andrew Hudacek, Joseph Rucker, Manu Mabila
Publikováno v:
Cancer Research. 77:74-74
The objective of this work was to evaluate the ability to generate panels of monoclonal antibodies against a set of highly challenging targets including GPCRs (CB1, C5AR, CXCR5 and CGRPR), transporters (GLUT4), and ion channels (P2X3). Integral membr