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pro vyhledávání: '"Lewis J. Kraft"'
Selective macroautophagy/autophagy—with the help of molecular receptors—captures cargo for lysosomal degradation. Among the best-studied molecular receptors is SQSTM1/p62, a homo-oligomeric ubiquitin binding protein, which binds to both cargo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ab1df2c40a1c895321e2d9417a13e5
https://europepmc.org/articles/PMC5082789/
https://europepmc.org/articles/PMC5082789/
Autor:
Victoria Campbell, Alar Ainla, Lewis J. Kraft, Mengxia Zhao, Mostafa Baghbanzadeh, Jerome M. Fox, George M. Whitesides, Kyungtae Kang, Sergey Semenov
Publikováno v:
Nature. 537(7622)
A few-component network of biologically relevant, organic reactions displays bistability and oscillations, without an enzymatic catalyst. Dissipative chemical reaction networks are systems that operate away from equilibrium and exhibit features such
Autor:
David E. Cliffel, Jennifer R. McKenzie, Eugene Kozlov, Rachel M. Snider, John P. Wikswo, Lewis J. Kraft
Publikováno v:
Toxins
Volume 2
Issue 4
Pages 632-648
Volume 2
Issue 4
Pages 632-648
Multianalyte microphysiometry, a real-time instrument for simultaneous measurement of metabolic analytes in a microfluidic environment, was used to explore the effects of cholera toxin (CTx). Upon exposure of CTx to PC-12 cells, anaerobic respiration
Publikováno v:
Traffic (Copenhagen, Denmark). 17(4)
MAP1LC3B (microtubule-associated protein 1 light chain 3, LC3) is a key component of the autophagy pathway, contributing to both cargo selection and autophagosome formation in the cytoplasm. Emerging evidence suggests that nuclear forms of LC3 are al
Autor:
Michael W. Davidson, Bing Han, Daniel J.-F. Chinnapen, Nicholas W. Baetz, Anne K. Kenworthy, Charles A. Day, Courtney A. Copeland, Randall K. Holmes, Kimberly R. Drake, Trina A. Schroer, Heidi De Luca, Lewis J. Kraft, Michael G. Jobling, Ajit Tiwari, Wayne I. Lencer
Publikováno v:
Traffic (Copenhagen, Denmark)
How the plasma membrane is bent to accommodate clathrin-independent endocytosis remains uncertain. Recent studies suggest Shiga and cholera toxin induce membrane curvature required for their uptake into clathrin-independent carriers by binding and cr
Autor:
Charles A. Day, Nicholas W. Baetz, Ajit Tiwari, Kimberly R. Drake, Courtney A. Copeland, Lewis J. Kraft, Bing Han, Daniel J. Chinnapen, Michael W. Davidson, Randall K. Holmes, Michael G. Jobling, Trina A. Schroer, Wayne I. Lencer, Anne K. Kenworthy
Publikováno v:
Biophysical Journal. 108(2)
Publikováno v:
Biophysical journal. 106(3)
Class 1 myosins are monomeric motor proteins that fulfill diverse functions at the membrane/cytoskeletal interface. All myosins-1 contain a motor domain, which binds actin, hydrolyzes ATP, and generates forces, and a TH1 domain, which interacts direc
LC3 Constitutively Associates with a High Molecular Weight Complex in Both the Cytoplasm and Nucleus
Autor:
Anne K. Kenworthy, Tuan A. Nguyen, Anthony J. Baucum, Lewis J. Kraft, Steven S. Vogel, Bing Han
Publikováno v:
Biophysical Journal. 104(2)
LC3 is a key component of the autophagy pathway, where it functions in autophagosome formation and cargo recruitment. Recent proteomics analysis indicates LC3 and other members of the ATG8 family interact with 67 different proteins, many of which app
Publikováno v:
Current Protocols in Cytometry
Fluorescence recovery after photobleaching (FRAP) is a powerful, versatile, and widely accessible tool to monitor molecular dynamics in living cells that can be performed using modern confocal microscopes. Although the basic principles of FRAP are si
Publikováno v:
Autophagy
Microtubule associated protein 1 light chain 3B (LC3/ATG8) functions in autophagosome formation and autophagy substrate recruitment. LC3 exists in both a soluble (autophagosome-independent) form as well as a lipid modified form that becomes tightly i