Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lewis J. Klunk"'
Autor:
Bernard Leblanc, Thomas A. Baillie, Hassan G. Fouda, Lisa A. Shipley, Scott J. Grossman, James D. Green, Ronald J. Gerson, Darcy G. Perkins, Lewis J. Klunk, Mitchell N. Cayen
Publikováno v:
Toxicology and Applied Pharmacology. 182:188-196
This report summarizes the deliberations of a multidisciplinary committee, sponsored by the Pharmaceutical Research and Manufacturers of America, on current "best practices" within the U.S. pharmaceutical industry in assessing the role of drug metabo
Autor:
Ian A. Blair, Feng-Yin Hsieh, Scott W. Womble, Robert F. Mayol, Brian J. Nobes, Charles A. Goldthwaite, Lewis J. Klunk
Publikováno v:
Analytical Chemistry. 68:2996-3001
Chemical reaction interface mass spectrometry (CRIMS) was coupled on-line with HPLC using a Vestec particle beam interface. A helium-assisted nebulizer provided added stability with no loss in accuracy or precision as compared to the thermospray nebu
Autor:
Steven Hansel, Lisa Zadjura, Tao Wang, Pin-Fang Lin, Richard J. Colonno, Celia D’Arienzo, Nicholas A. Meanwell, Anthony M. Marino, Lewis J. Klunk, Douglas S. Greene, Kenneth S. Santone, Zheng Yang
Publikováno v:
Biopharmaceuticsdrug disposition. 26(9)
BMS-378806 is a prototype of novel HIV attachment inhibitors that block the gp120 and CD4 interaction, the first step of HIV-1 entry into cells. The present work investigated the pharmacokinetics of BMS-378806 in rats, dogs and monkeys and assessed i
Autor:
Lewis J. Klunk, Donglu Zhang, Renke Dai, Lifei Wang, Narayanan Narasimhan, James Mitroka, Nuggehally R. Srinivas, Richard A. Reeves, Jianing Zeng, Rajesh Krishna
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(1)
MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one); BMS-204352] is an investigational maxi-K channel opener to treat ischemic stroke. This study reports the disposition, metabolism, pharmacokinetic
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(5)
MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one), or BMS-204352)] is a potent and specific maxi-K channel opener for potential use to treat stroke. This article describes structural characterizat
Autor:
James Mitroka, Donglu Zhang, Renke Dai, Lewis J. Klunk, Vikram Roongta, Richard Gedamke, J. Kent Rinehart, Marc Ogan, Mingshe Zhu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(7)
(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one) (MaxiPost, BMS-204352) is a potent and specific opener for maxi-K channels and has potential to prevent and treat ischemic stroke. Following single intraven
Publikováno v:
Cancer chemotherapy and pharmacology. 40(3)
Purpose: The chimeric BR96–doxorubicin (DOX) immunoconjugate, BMS 182248, has induced remissions and cures of human lung adenocarcinoma (L2987) implanted in athymic mice. The purpose of this study was to evaluate the biodistribution of DOX after BM
Publikováno v:
Journal of chromatography. 572(1-2)
A high-performance liquid chromatographic (HPLC) method for the determination of 9-[(2-phosphonylmethoxy)ethyl]adenine (PMEA) in urine is described. The procedure includes treatment of the urine sample with chloroacetaldehyde to form the fluorescent
Publikováno v:
Biomedicalenvironmental mass spectrometry. 19(5)
Metabolism of the antipsychotic drug tiospirone was studied in vitro with phenobarbital-induced rat liver microsomes. Metabolites were isolated and purified to homogeneity by high-performance liquid chromatography. It was possible to characterize the
Autor:
Lewis J. Klunk, George F. Kalf
Publikováno v:
Archives of Biochemistry and Biophysics. 177:585-593
Mitochondrial DNA polymerase (DNA polymerase mt) exists in two active forms. DNA polymerase present in crude extract (M-I) and ammonium sulfate precipitate (M-II) stages of purification sediments at 12.1S. The enzyme at the M-II stage of purification