Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lewis J. Archibald"'
Autor:
Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
p53 is an important tumor suppressor protein which is regulated by the E3 ubiquitin ligase MDM2. Here the authors reveal that DNA damage-induced Ser429 phosphorylation of MDM2 serve to boost the activity of MDM2 homodimer by stabilizing the active E2
Externí odkaz:
https://doaj.org/article/80e8bf383dda460bb88d16b6b1cd6555
Autor:
Lewis J. Archibald, Andrew G. Jamieson, Amit Mahindra, Iona Black, Christopher J. Millard, John W.R. Schwabe
Publikováno v:
Organic Letters. 21:3178-3182
[Image: see text] Syntheses of Fmoc amino acids having zinc-binding groups were prepared and incorporated into substrate inhibitor H3K27 peptides using Fmoc/(t)Bu solid-phase peptide synthesis (SPPS). Peptide 11, prepared using Fmoc-Asu(NHO(t)Bu)-OH,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269285a53900702f8836e7128c2c6c8d
https://doi.org/10.1021/acs.orglett.9b00885
https://doi.org/10.1021/acs.orglett.9b00885
Autor:
Syed Faisal Ahmed, Andrew G. Jamieson, Andreas K. Hock, Helge M. Magnussen, Karen H. Vousden, Ventzislava A. Hristova, Lewis J. Archibald, Danny T. Huang, Gary J. Sibbet, Koji Nomura, David Fushman, Allan M. Weissman
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Phosphorylation of MDM2 by ATM upon DNA damage is an important mechanism for deregulating MDM2, thereby leading to p53 activation. ATM phosphorylates multiple residues near the RING domain of MDM2, but the underlying molecular basis for deregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d3ed69811ec6623d16c2a382921ed6
https://pubmed.ncbi.nlm.nih.gov/32350255
https://pubmed.ncbi.nlm.nih.gov/32350255
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491c16c6dcfba0e1c320a76616ec1f72
http://hdl.handle.net/2445/127746
http://hdl.handle.net/2445/127746
