Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lewin SM"'
Autor:
Le May Thai, Liam O’Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A. Kebede, Robert Brink, Gregory J. Cooney, Katharine M. Irvine, Samuel N. Breit, Tri G. Phan, Alexander Swarbrick, Trevor J. Biden
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106477- (2023)
Summary: We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling) polarization. Unde
Externí odkaz:
https://doaj.org/article/f164ff5bf0454edab4a24997c1c6486a
Autor:
Amanda E Brandon, Lewin Small, Tuong-Vi Nguyen, Eurwin Suryana, Henry Gong, Christian Yassmin, Sarah E Hancock, Tamara Pulpitel, Sophie Stonehouse, Letisha Prescott, Melkam A Kebede, Belinda Yau, Lake-Ee Quek, Greg M Kowalski, Clinton R Bruce, Nigel Turner, Gregory J Cooney
Publikováno v:
eLife, Vol 11 (2022)
Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin sensitive. Similarly, recent work suggests that mice fed h
Externí odkaz:
https://doaj.org/article/db007dc4da554290aad890aa013d0767
Autor:
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trošt, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barrès
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101440- (2022)
Objective: The glucose tolerance test (GTT) is widely used in preclinical research to investigate glucose metabolism, but there is no standardised way to administer glucose. The aim of this study was to directly compare the effect of the route of glu
Externí odkaz:
https://doaj.org/article/77e12f244ee14592b5d0b6bff12b2c30
Autor:
Kristine Williams, Lars R. Ingerslev, Jette Bork-Jensen, Martin Wohlwend, Ann Normann Hansen, Lewin Small, Rasmus Ribel-Madsen, Arne Astrup, Oluf Pedersen, Johan Auwerx, Christopher T. Workman, Niels Grarup, Torben Hansen, Romain Barrès
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammator
Externí odkaz:
https://doaj.org/article/6a8adde43f8e4a568fb7abbf52f498c8
Autor:
Lewin Small, Amanda E. Brandon, Benjamin L. Parker, Vinita Deshpande, Azrah F. Samsudeen, Greg M. Kowalski, Jane Reznick, Donna L. Wilks, Elaine Preston, Clinton R. Bruce, David E. James, Nigel Turner, Gregory J. Cooney
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 107-118 (2019)
Objective: Energy metabolism and insulin action follow a diurnal rhythm. It is therefore important that investigations into dysregulation of these pathways are relevant to the physiology of this diurnal rhythm. Methods: We examined glucose uptake, ma
Externí odkaz:
https://doaj.org/article/db9fca57c93a4a79959a2db147f25fc7
Autor:
Lewin Small, Lars R Ingerslev, Eleonora Manitta, Rhianna C Laker, Ann N Hansen, Brendan Deeney, Alain Carrié, Philippe Couvert, Romain Barrès
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009325 (2021)
In response to physical exercise and diet, skeletal muscle adapts to energetic demands through large transcriptional changes. This remodelling is associated with changes in skeletal muscle DNA methylation which may participate in the metabolic adapta
Externí odkaz:
https://doaj.org/article/b980783ce524444ea61f6aac736af9c6
Akademický článek
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Akademický článek
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Publikováno v:
Psychiatric Services; Jan2007, Vol. 58 Issue 1, p12-14, 3p
Autor:
Magdalene K. Montgomery, Brenna Osborne, Simon H.J. Brown, Lewin Small, Todd W. Mitchell, Gregory J. Cooney, Nigel Turner
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3322-3333 (2013)
Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation and insulin resistance, diets rich in medium-chain fatty acids (MCFAs) have been associated w
Externí odkaz:
https://doaj.org/article/c71ce22b12e344e59963ff23e7207160