Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Levuglandin"'
Publikováno v:
Chemical Science
Natural systems produce various γ-dicarbonyl-bearing compounds that can covalently modify lysine in protein targets via the classic Paal–Knorr reaction. Among them is a unique class of lipid-derived electrophiles – isoketals that exhibit high ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37706e0340887244656b5b6d5fcd5e70
https://doi.org/10.1039/d1sc02230j
https://doi.org/10.1039/d1sc02230j
Publikováno v:
Molecules, Vol 16, Iss 7, Pp 5333-5348 (2011)
Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, formi
Externí odkaz:
https://doaj.org/article/639f47512a8b42d1b33eeb8cd7237115
Autor:
C. Blake Sullivan, Elena Matafonova, L. Jackson Roberts, II, Venkataraman Amarnath, Sean S. Davies
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 999-1009 (2010)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions
Externí odkaz:
https://doaj.org/article/2734229a4cd34f52a4bd8558ff93b624
Autor:
Erica J. Carrier, Venkataraman Amarnath, Olivier Boutaud, Irene Zagol-Ikapitte, John A. Oates
Publikováno v:
Biochemistry
Inflammation and subsequent cyclooxygenase-2 (COX-2) activity has long been linked with the development of cancer, although little is known about any epigenetic effects of COX-2. A product of COX-2 activation, levuglandin (LG) quickly forms covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41411cc2dee8acdf415580aaeda987b3
http://europepmc.org/articles/PMC4004227
http://europepmc.org/articles/PMC4004227
Autor:
Yuko Cho, Keiichi Konoki, Mirriam F. Cayme, Hiroyuki Koshino, Sadahiko Hiroki, Yoshikazu Kanai, Yasuo Fukuyo, Mari Yotsu-Yamashita
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 12, Pp 2245-2254 (2011)
In animals, the product of cyclooxygenase reacting with arachidonic acid, prostaglandin(PG)H(2), can undergo spontaneous rearrangement and nonenzymatic ring cleavage to form levuglandin(LG)E(2) and LGD(2). These LGs and their isomers are highly react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a3b64faeba87aa4483d4e22e1ec1f4
http://www.sciencedirect.com/science/article/pii/S0022227520408284
http://www.sciencedirect.com/science/article/pii/S0022227520408284
Autor:
Sean S. Davies, Elena Matafonova, L. Jackson Roberts, C. Blake Sullivan, Venkataraman Amarnath
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 999-1009 (2010)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are gamma-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf29ff985d467902129510183bba4ec
https://doi.org/10.1194/jlr.m001040
https://doi.org/10.1194/jlr.m001040
Autor:
Rudy J. Castellani, Evelyn Fakhoury, Mark A. Smith, William J. Walsh, Xiongwei Zhu, Woody R. McGinnis, Stanley L. Hazen, Zeneng Wang, George Perry, Teresa A. Evans, Liang Lu, Robert G. Salomon, Allen Lewis, Sandra L. Siedlak, Xiaoming Fu
Publikováno v:
American Journal of Biochemistry and Biotechnology. 4:61-72
Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and iso[4]levuglandin (iso[4]LG)E2-protein adducts, that are unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a3b62f5918d023fd6d6a921f7248cf
https://doi.org/10.3844/ajbbsp.2008.61.72
https://doi.org/10.3844/ajbbsp.2008.61.72
Autor:
John A. Oates, Irene Zagol-Ikapitte, Tina S. Masterson, Thomas J. Montine, Olivier Boutaud, V. Amarnath, Katrin I. Andreasson
Publikováno v:
Journal of Neurochemistry. 94:1140-1145
The formation of cyclooxygenase-derived lipid adducts of protein in brains of patients who had Alzheimer's disease has been investigated. The enzymatic product of the cyclooxygenases, prostaglandin H2, rearranges in part to highly reactive γ-ketoald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c7aabe11b484944bafa7512a257e437
https://doi.org/10.1111/j.1471-4159.2005.03264.x
https://doi.org/10.1111/j.1471-4159.2005.03264.x
Publikováno v:
The Journal of Organic Chemistry. 59:6038-6043
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4655a54bd98f094df4ca034b6f5e98c
https://doi.org/10.1021/jo00099a039
https://doi.org/10.1021/jo00099a039
Autor:
John A. Oates, Venkataraman Amarnath, Olivier Boutaud, Nathalie Bernoud-Hubac, Irene Zagol-Ikapitte, L. Jackson Roberts
Publikováno v:
Biochemistry. 43:5503-5510
Levuglandins are gamma-keto aldehydes formed by rearrangement of prostaglandin (PG) H(2) in aqueous solution. Levuglandins are highly reactive with primary amines. We had previously characterized adducts formed after reaction of levuglandin E(2) (LGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2990215b576e641afc16e3093a6aa52
https://doi.org/10.1021/bi049842r
https://doi.org/10.1021/bi049842r