Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Levon D. Movsisyan"'
Autor:
Andreas Nguyen, Gerd Gemmecker, Charlotte A. Softley, Levon D. Movsisyan, Toni Pfaffeneder, Andreas Heine, Klaus Reuter, François Diederich, Michael Sattler, Gerhard Klebe
Publikováno v:
ACS Chemical Biology, 17 (7)
ACS Chem. Biol. 17, 1745-1755 (2022)
ACS Chem. Biol. 17, 1745-1755 (2022)
Understanding the structural arrangements of protein oligomers can support the design of ligands that interfere with their function in order to develop new therapeutic concepts for disease treatment. Recent crystallographic studies have elucidated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8664557d526ab2c921197f810ee16b02
https://hdl.handle.net/20.500.11850/558323
https://hdl.handle.net/20.500.11850/558323
Autor:
F. Wieland Goetzke, Tobias Hüfner-Wulsdorf, François Diederich, Christoph Hohn, Klaus Reuter, F.R. Ehrmann, Maurice Sebastiani, Adrian Härtsch, E. Hassaan, Gerhard Klebe, Levon D. Movsisyan
Publikováno v:
Journal of Medicinal Chemistry, 63 (13)
Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in Shigella, the causative agent of shigellosis. TGT inhibition prevents translation of Shigella's virulence factor VirF, hen
Publikováno v:
Organicbiomolecular chemistry. 18(30)
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune system. Siglecs recognize sialic acid via their terminal V-set domain. In m
Autor:
Anatol Schwab, Elisabeth Schäfer, Gerhard Klebe, Levon D. Movsisyan, F.R. Ehrmann, A. Nguyen, Björn Wagner, Hamina Daff, Daniel Zimmerli, Andreas Heine, François Diederich, Thomas Rossolini
Publikováno v:
Chemistry - A European Journal. 24:9957-9967
The intestinal disease shigellosis caused by Shigella bacteria affects over 120 million people annually. There is an urgent demand for new drugs as resistance against common antibiotics emerges. Bacterial tRNA-guanine transglycosylase (TGT) is a drug
Autor:
Michael Franz, Christian Neiss, Rik R. Tykwinski, Levon D. Movsisyan, Harry L. Anderson, Dominik Wendinger, Johanna A. Januszewski, Frank Hampel, Andreas Görling
Publikováno v:
Angewandte Chemie International Edition. 54:6645-6649
The stabilization of long [n]cumulenes has traditionally been achieved by placing sterically bulky "protecting groups" at the termini, which shield the reactive carbon chain from unwanted reactions. Herein, we present an alternative strategy: stabili
Autor:
Christian Neiss, Rik R. Tykwinski, Michael Franz, Harry L. Anderson, Levon D. Movsisyan, Dominik Wendinger, Johanna A. Januszewski, Andreas Görling, Frank Hampel
Publikováno v:
Angewandte Chemie. 127:6746-6750
Die Stabilisierung langer [n]Cumulene wird ublicherweise erreicht, indem sterisch anspruchsvolle “Schutzgruppen” an den Enden angebracht werden, welche die reaktive Kohlenstoffkette abschirmen. Wir stellen hier eine alternative Strategie vor: Sta
Autor:
Michael Franz, Colin J. Lambert, Maximilian Krempe, Iain Grace, Richard J. Nichols, Simon J. Higgins, Levon D. Movsisyan, Harry L. Anderson, Walther Schwarzacher, David C. Milan, Richard J. Brooke, Rik R. Tykwinski, Ali K. Ismael
Publikováno v:
NANOSCALE
Milan, D C, Krempe, M, Ismael, A K, Ismael, A K, Movsisyan, L D, Franz, M, Grace, I, Brooke, R J, Schwarzacher, W, Higgins, S J, Anderson, H L, Lambert, C J, Tykwinski, R R & Nichols, R J 2017, ' The single-molecule electrical conductance of a rotaxane-hexayne supramolecular assembly ', Nanoscale, vol. 9, no. 1, pp. 355-361 . https://doi.org/10.1039/c6nr06355a
Milan, D C, Krempe, M, Ismael, A K, Ismael, A K, Movsisyan, L D, Franz, M, Grace, I, Brooke, R J, Schwarzacher, W, Higgins, S J, Anderson, H L, Lambert, C J, Tykwinski, R R & Nichols, R J 2017, ' The single-molecule electrical conductance of a rotaxane-hexayne supramolecular assembly ', Nanoscale, vol. 9, no. 1, pp. 355-361 . https://doi.org/10.1039/c6nr06355a
Oligoynes are archetypical molecular wires due to their 1-D chain of conjugated carbon atoms and ability to transmit charge over long distances by coherent tunneling. However, the stability of the oligoyne can be an issue. Here we address this proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49acdaaf9a4c9fc856666443f48af30
Autor:
Michael Towrie, Harry L. Anderson, Levon D. Movsisyan, Martin D. Peeks, Gregory M. Greetham, Amber L. Thompson, Anthony W. Parker
Publikováno v:
Journal of the American Chemical Society
We have used single-crystal X-ray diffraction and time-resolved UV-NIR-IR absorption spectroscopy to gain insights into the structures and excited-state dynamics of a rotaxane consisting of a hexayne chain threaded through a phenanthroline macrocycle
Autor:
Levon D. Movsisyan, Dmitry V. Kondratuk, Harry L. Anderson, Michael Franz, Amber L. Thompson, Rik R. Tykwinski
Publikováno v:
Organic letters. 14(13)
Active-metal templating has been used to synthesize rotaxanes consisting of a phenanthroline-based macrocycle threaded around a C8, C12, or C20 polyyne chain. The crystal structure of the C12 rotaxane has been determined. In the rhenium(I) carbonyl c
Autor:
Christian Neiss, Rik R. Tykwinski, Michael Franz, Harry L. Anderson, Dominik Wendinger, Levon D. Movsisyan, Frank Hampel, Johanna A. Januszewski, Andreas Görling
Publikováno v:
Angewandte Chemie. 127:6472-6472