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Transcription factor combinations determine gene locus activity and thereby cell identity. However, the precise link between concentrations of such activating transcription factors and target-gene activity is ambiguous. Here we investigate this link
Externí odkaz:
http://arxiv.org/abs/2308.05685
Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods, governing mRNA production rates. Yet, how transcription is regulated through bursting dynamics remains unresolved. Here, we conduct real-time measu
Externí odkaz:
http://arxiv.org/abs/2304.08770
Autor:
Pau Codina, David Dobarro, Javier deJuan‐Bagudá, Fernando De Frutos, Josep Lupón, Antoni Bayes‐Genis, José Gonzalez‐Costello, Spanish LEVO‐D registry Collaborators
Publikováno v:
ESC Heart Failure, Vol 10, Iss 5, Pp 2875-2881 (2023)
Abstract Aims The prevalence of advanced heart failure (HF) is increasing due to the growing number of patients with HF and their better treatment and survival. There is a scarcity of data on the accuracy of HF web‐based risk scores in this selecte
Externí odkaz:
https://doaj.org/article/08179249381e4e95b71e457b0093bbe2
Publikováno v:
In Developmental Cell 4 December 2023 58(23):2789-2801
Autor:
Jeffrey M. Boertien, Kirsi Murtomäki, Pedro A. B. Pereira, Sygrid van der Zee, Tuomas H. Mertsalmi, Reeta Levo, Tanja Nojonen, Elina Mäkinen, Elina Jaakkola, Pia Laine, Lars Paulin, Eero Pekkonen, Valtteri Kaasinen, Petri Auvinen, Filip Scheperjans, Teus van Laar, PPNN Study Group
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Gut microbiota alterations in Parkinson’s disease (PD) have been found in several studies and are suggested to contribute to the pathogenesis of PD. However, previous results could not be adequately adjusted for a potential confounding eff
Externí odkaz:
https://doaj.org/article/8190dbfd723046688afdf55eea320d34
Akademický článek
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Autor:
Kirsi Murtomäki, Juho Joutsa, Tuomas Mertsalmi, Elina Jaakkola, Elina Mäkinen, Reeta Levo, Mikael Eklund, Simo Nuuttila, Eero Pekkonen, Tommi Noponen, Toni Ihalainen, Valtteri Kaasinen, Filip Scheperjans
Publikováno v:
Brain and Behavior, Vol 13, Iss 7, Pp n/a-n/a (2023)
Abstract Background Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry p
Externí odkaz:
https://doaj.org/article/4e9997aad2ec4a8f9f0a7e59a537f689
Autor:
Valtteri Räty, Mikael Eklund, Simo Nuuttila, Elina Jaakkola, Elina Mäkinen, Kirsi Murtomäki, Tanja Nojonen, Reeta Levo, Tuomas Mertsalmi, Juho Joutsa, Filip Scheperjans, Valtteri Kaasinen
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 8, Iss , Pp 100184- (2023)
Diagnostic usefulness of the floating door sign was tested in 144 PD patients, 41 essential tremor patients and 38 controls. There were no differences in the presence of floating door sign between PD and ET patients. The sign does not seem to be a re
Externí odkaz:
https://doaj.org/article/9a80f73f33b0461ea85fddeaf7d497d7
Akademický článek
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Publikováno v:
In Computational Materials Science September 2021 197