A Phase I Randomized Study of a Specifically Engineered, pH-Sensitive PCSK9 Inhibitor RN317 (PF-05335810) in Hypercholesterolemic Subjects on Statin Therapy.

Autor: Levisetti, M¹, Joh, T¹, Wan, H², Liang, H², Forgues, P², Gumbiner, B¹, Garzone, PD² Pamela.Garzone@pfizer.com

Publikováno v: CTS: Clinical & Translational Science. Jan2017, Vol. 10 Issue 1, p3-11. 9p.

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Autor: Ridker, P. M., Revkin, J., Amarenco, P., Brunell, R., Civeira, F., Flather, M., Glynn, R. J., Gregoire, J., Jukema, J. W., Karpov, Y., Kastelein, J. J. P., Koenig, W., Lorenzatti, A., Manga, P., Masiukiewicz, U., Miller, M., Mosterd, A., Murin, J., Nicolau, J. C., Nissen, S., Ponikowski, P., Santos, R. D., Schwartz, P. F., Soran, H., White, H., Wright, R. S., Vrablik, M., Yunis, C., Shear, C. 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Gillespie, E, Bybee, Ka, Moriarty, Pm, Savin, V, Agaiby, Jm, Melucci, Mb, Jantzi, Cm, Davidson, E, Smith, Wb, Treasure, Cb, Wakefield, Ph, Deck, K, Edris, Ma, Gilmore, Rm, Seep, Mk, Andersen, Jl, Detweiler, Ro, Rosenfeld, Jc, Strobl, Dj, Steinhoff, Jp, Adams, A, Estevez, R, Molin, Cj, Kim, Cy, Dy, J, Fox, Ke, Farris, Nr, Wayne, Jd, Whitney, Rt, Randhawa, Pm, Mego, Dm, Macdolnald, L, Caputo, Rp, Rigolosi, R, Vannatta, B, Pacheco, Tr, El-Shahawy, M, Gonzalez, Ej, Guice, Mj, Cherlin, Rs, Bays, He, Shoukfeh, M, Morris, Fh, Loy, J, Vora, Sk, Staab, Pk, Frisoli, A, Kimmel, Ma, Cohen, Aj, Green, Cb, Whitlock, L, Butuk, Dj, Mccartney, Mj, Ables, Lr, Acosta, R, Alvarez, Jg, Barrera, Cm, Benitez, O, Berenguer, Ra, Breton, Cf, Chiong, R, Delgado, Mi, Dufreny, A, Fialkow, Ja, Franczek, S, Frias, Jj, Iglesias, C, Landron-Garcia, L, Llerena, Sn, Martinez, Rf, Miranda, Aa, Morytko, Ja, Rodriguez, Ij, Sotolongo, R, Suarez-Sarmiento, A, Terrelonge, Ae, Vaca, Ce, Venereo, Jm, Verdeza, C, Zeno, Ml, 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Publikováno v: The New England Journal of Medicine, 376, 16, pp. 1527-1539
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2017, 376 (16), pp.1527-1539. ⟨10.1056/NEJMoa1701488⟩
New England Journal of Medicine, 376(16), 1527-1539. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 376(16), 1527. Massachussetts Medical Society
The New England Journal of Medicine, 376, 1527-1539
Department of Medicine Publications
Ridker, P M, Revkin, J, Amarenco, P, Brunell, R, Curto, M, Civeira, F, Flather, M, Glynn, R J, Gregoire, J, Jukema, J W, Karpov, Y, Kastelein, J J P, Koenig, W, Lorenzatti, A, Manga, P, Masiukiewicz, U, Miller, M, Mosterd, A, Murin, J, Nicolau, J C, Nissen, S, Ponikowski, P, Santos, R D, Schwartz, P F, Soran, H, White, H, Wright, R S, Vrablik, M, Yunis, C, Shear, C L, Tardif, J-C, SPIRE Cardiovascular Outcome Investigators & Michael Jepsen, J 2017, ' Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients ', The New England Journal of Medicine, vol. 376, no. 16, pp. 1527-1539 . https://doi.org/10.1056/NEJMoa1701488
New England Journal of Medicine, 376(16), 1527-1539
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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New England journal of medicine, 376(16), 1527-1539. Massachussetts Medical Society

Item does not contain fulltext BACKGROUND: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48145f0e532c28c7df2dafc05d62159
https://hdl.handle.net/2066/182257

Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes.

Autor: Williams JH; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA. jason.williams@pfizer.com., Udata C; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA., Ganguly BJ; Pfizer Inc, South San Francisco, California, USA.; Lyell Immunopharma, South San Francisco, California, USA., Bucktrout SL; Pfizer Inc, South San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, California, USA., Joh T; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA., Shannon M; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA., Wong GY; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA., Levisetti M; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.; DNAtrix Therapeutics, San Diego, California, USA., Garzone PD; Pfizer Inc, South San Francisco, California, USA.; Calibr, a division of Scripps Research, La Jolla, California, USA., Meng X; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.

Publikováno v: The AAPS journal [AAPS J] 2020 Jan 03; Vol. 22 (2), pp. 23. Date of Electronic Publication: 2020 Jan 03.

The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.

Autor: Gumbiner B; Pfizer Inc., South San Francisco and San Diego, CA, USA., Joh T; Pfizer Inc., South San Francisco and San Diego, CA, USA., Liang H; Pfizer Inc., South San Francisco and San Diego, CA, USA., Wan H; Pfizer Inc., South San Francisco and San Diego, CA, USA., Levisetti M; Pfizer Inc., South San Francisco and San Diego, CA, USA., Vana AM; Pfizer Inc., South San Francisco and San Diego, CA, USA., Shelton DL; Pfizer Inc., South San Francisco and San Diego, CA, USA., Forgues P; Pfizer Inc., South San Francisco and San Diego, CA, USA., Billotte S; Pfizer Inc., South San Francisco and San Diego, CA, USA., Pons J; Pfizer Inc., South San Francisco and San Diego, CA, USA., Baum CM; Mirati Therapeutics Inc., San Diego, CA, USA., Garzone PD; Pfizer Inc., South San Francisco and San Diego, CA, USA.

Publikováno v: Cardiovascular therapeutics [Cardiovasc Ther] 2018 Feb; Vol. 36 (1). Date of Electronic Publication: 2017 Nov 23.

Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease.

Autor: Tesar V; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Vladimir.Tesar@vfn.cz., Ciechanowski K; Department of Nephrology, Pomeranian Medical University, Szczecin, Poland., Pei Y; Division of Nephrology, University Health Network, Toronto, Ontario, Canada., Barash I; Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York., Shannon M; Worldwide Research and Development, Pfizer Inc, San Diego, California., Li R; Early Oncology Development and Clinical Research and., Williams JH; Worldwide Research and Development, Pfizer Inc, San Diego, California., Levisetti M; Worldwide Research and Development, Pfizer Inc, San Diego, California., Arkin S; Worldwide Research and Development, Pfizer Inc, Cambridge, Massachusetts; and., Serra A; Suisse ADPKD, Institute of Internal Medicine and Nephrology, Klinik Hirslanden, Zürich, Switzerland.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2017 Nov; Vol. 28 (11), pp. 3404-3413. Date of Electronic Publication: 2017 Aug 24.