Chromosomal coordination and differential structure of asynchronous replicating regions

Autor: Britny Blumenfeld, Hagit Masika, Marganit Farago, Yishai Yehuda, Lamia Halaseh, Oriya Vardi, Rachel Rapoport, Rena Levin-Klein, Howard Cedar, Yehudit Bergman, Itamar Simon

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Most regions of the mammalian genome replicate both alleles in a synchronous manner, but some loci have been found to replicate asynchronously and the time of replication of each allele is different. Here the authors, by employing clonal mouse cells

Externí odkaz: https://doaj.org/article/5a44785bc8d24207acd6f75995d67d94

Postnatal DNA demethylation and its role in tissue maturation

Autor: Yitzhak Reizel, Ofra Sabag, Yael Skversky, Adam Spiro, Benjamin Steinberg, Diana Bernstein, Amber Wang, Julia Kieckhaefer, Catherine Li, Eli Pikarsky, Rena Levin-Klein, Alon Goren, Klaus Rajewsky, Klaus H. Kaestner, Howard Cedar

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue

Externí odkaz: https://doaj.org/article/50520c8d9e7d4a71beda66e83fbcd1e0

Clonally stable Vκ allelic choice instructs Igκ repertoire

Autor: Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar, Yehudit Bergman

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochas

Externí odkaz: https://doaj.org/article/a60058be570b46449a317fcb6741376b

Human APOBEC3B promotes tumor heterogeneityin vivoincluding signature mutations and metastases

Autor: Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P. Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M. Holzhauer, Zachary J. Seeman, Yu-Hsiu T. Lin, Rachel I. Vogel, Rocio Sotillo, Hilde Nilsen, Reuben S. Harris

Publikováno v: bioRxiv

SUMMARYThe antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many different cancers. Despite over 10 years of work, a causal relationship has yet to be established between APOBEC3B and any stage of carcinogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682eb7defe301f13f4ecb2994a77c819
https://doi.org/10.1101/2023.02.24.529970

Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

Autor: Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P., Alsøe, Lene, Carracedo Huroz, Sergio, Alonso de la Vega, Alicia, Proehl, Joshua, Holzhauer, Anna M., Seeman, Zachary J., Liu, Xingyu, Lin, Yu-Hsiu T., Vogel, Rachel I., Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S.

Publikováno v: Durfee, Cameron Temiz, Nuri Alpay Levin-Klein, Rena Argyris, Prokopios P. Alsøe, Lene Carracedo Huroz, Sergio Alonso de la Vega, Alicia Proehl, Joshua Holzhauer, Anna M. Seeman, Zachary J. Liu, Xingyu Lin, Yu-Hsiu T. Vogel, Rachel I. Sotillo, Rocio Nilsen, Hilde Harris, Reuben S. . Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases. Cell Reports Medicine. 2023, 4:101211(10), 1-26
Cell Reports Medicine

Externí odkaz: http://hdl.handle.net/10852/107595